Vector-borne RADAR (Real-time Arbovirus Detection And Response)

媒介传播雷达（实时虫媒病毒检测和响应）

基本信息

批准号：
BB/X017990/1
负责人：
Arran Folly
金额：
$ 117.73万
依托单位：
ANIMAL AND PLANT HEALTH AGENCY
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FX017990%2F1
关键词：
Vector borne RADAR Real time

项目摘要

Vector-borne RADAR looks to enhance surveillance of mosquito-borne diseases of wild birds in the UK that have wider medical and veterinary importance by adopting a One Health approach. Our first work package will increase the scope of our successful, multi-disciplinary network, which was responsible for the detection of Usutu virus in the UK in 2020, to include additional routes for sampling both bird hosts and mosquito vectors. This will follow a similar and successful paradigm that has been used in the Netherlands to detect emerging mosquito borne viruses of wild birds (www.onehealthpact.org). In essence we will co-opt bird observatories and licensed ringers in areas deemed at high-risk of virus incursion to sample migrant birds (to identify potential routes of virus incursion) and resident birds (to elucidate geographic extent and virus prevalence). At each of our designated bird sampling sites we will also set up mosquito traps to provide information on vector community composition, virus prevalence and potential transmission networks. Our second work package will develop an early warning system for the detection of potential zoonotic viral diseases of wild birds in the UK. Two existing and independent citizen science data schemes (the British Trust for Ornithology's [BTO] Garden BirdWatch, and the Garden Wildlife Health [GWH] project) will be co-opted to identify clusters of disease incident reports which correlate with a reduction in wild bird reporting rates, as a proxy to indicate areas of virus circulation and assess near real-time impact. This approach has been shown to be successful, by our consortium, in retrospectively identifying patterns of Blackbird mortality and declines in reporting rates caused by the 2020 Usutu virus outbreak in the UK. Our third work package will be conducted in collaboration with citizen scientists who participate in the BTO Garden BirdWatch. We will undertake a survey aiming to understand fine-scale Blackbird movements and habitat use in UK gardens. Data generated will provide detail on specific habitat use and identify potential virus transmission risks in relation to habitat features of gardens that are also likely to encourage higher mosquito populations (e.g. areas of stagnant water). Alongside this we will establish Blackbird trapping sites in London and the south-east, where licensed ringers will aim to catch birds in mist nets and colour-ring (so they can be identified from a distance without the need for further trapping) individual Blackbirds in order to quantify survival rates through time. Ringers involved in the scheme will also be trained to deploy mosquito traps and identify mosquitoes to provide evidence to link vector abundance and disease prevalence directly to wild bird survival.The data generated from this research proposal will improve our understanding of how exotic mosquito-borne viruses emerge and persist in temperate areas while also feeding directly into government policy & risk assessments on zoonotic diseases, public health messages and mosquito control strategies. Through engagement with citizen scientists, wildlife rehabilitators, zoological collections, and animal welfare and conservation NGOs, we will also raise awareness of implications for animal health and impacts on biodiversity.

媒介传播的雷达旨在增强英国野生鸟类蚊子传播疾病的监视，这些野生鸟类通过采用一种健康方法，这些野生鸟类具有更广泛的医学和兽医的重要性。我们的第一个工作包将增加我们成功的多学科网络的范围，该网络负责在2020年在英国发现USUTU病毒，以包括对鸟类宿主和蚊子载体进行采样的其他路线。这将遵循类似的成功范式，该范式已在荷兰使用，以检测野生鸟类的新兴蚊子传播病毒（www.onehealthpact.org）。从本质上讲，我们将在高风险的病毒入侵的地区选择鸟类的观测站和有执照的铃声，以采样移民鸟类（以识别病毒入侵的潜在途径）和常驻鸟类（阐明地理位置范围和病毒患者的流行）。在我们指定的鸟类采样地点，我们还将建立蚊子陷阱，以提供有关媒介社区组成，病毒流行和潜在传输网络的信息。我们的第二个工作包将开发一个预警系统，用于检测英国野生鸟类潜在的人畜共患病毒疾病。将对两种现有和独立的公民科学数据方案（英国对鸟类学的[BTO]花园观鸟和花园野生动植物健康[GWH]项目）的选择，以确定疾病事件事件报告群，这些报告与野生鸟报告降低相关的疾病事件事件报告，以表明病毒循环和接近实时的时间影响。我们的财团证明了这种方法是在回顾性地识别黑鸟死亡率的模式和由2020年英国2020年USUTU病毒爆发引起的报告率下降的模式的成功。我们的第三个工作套餐将与参加BTO Garden Birdwatch的公民科学家合作进行。我们将进行一项调查，旨在了解英国花园中的细大规模黑鸟运动和栖息地的使用。产生的数据将提供有关特定栖息地的详细信息，并确定与花园的栖息地特征有关的潜在病毒传播风险，这些风险也可能鼓励更高的蚊子种群（例如停滞的水域）。在此旁边，我们将在伦敦和东南部建立黑鸟诱捕地点，在那里有执照的铃声将旨在捕捉雾网和颜色环（因此可以从远处识别出无需进一步捕获的鸟），以便通过时间来量化生存率。参与该计划的铃声还将接受培训，以部署蚊子陷阱并确定蚊子以将媒介丰度和疾病流行与野生鸟的生存联系起来。从这项研究建议中产生的数据将提高我们对异国蚊子 - 蚊子 - - 蚊子 - - 蚊子病毒的理解，同时又在政府范围内迅速侵害了Zoone Cromist和摩西群岛，并将其持续不断地侵害了Zoone的策略和摩西群体，并将其直接评估为莫克斯克人。通过与公民科学家，野生动植物康复者，动物学收集以及动物福利和保护非政府组织的参与，我们还将提高人们对动物健康的影响以及对生物多样性的影响的认识。