21ENGBIO: Plant microcompartment engineering for green production

21ENGBIO：绿色生产的植物微室工程

• 批准号: BB/W013096/1
• 负责人: Elizabete Carmo-Silva
• 金额: $ 11.08万
• 依托单位: Lancaster University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FW013096%2F1
• 关键词: 21ENGBIO; Plant; microcompartment; engineering; green

The myriad pressures on the environment and industry mean that greener methods must be developed for producing the materials and products society needs. Plants provide the majority of the renewable products and materials we use, and through engineering provide tremendous opportunities to further innovate upon their uses in the bioeconomy to achieve profitable, scalable, sustainable production. This Engineering Biology Breakthroughs Award research will engineer an innovative system based on bacterial microcompartments to expand the potential of plants as biofactories for industries from biomedicine to bioplastics.It's key aims are to:(1) install a bacterial microcompartment shell within plants as a scaffold for encapsulating novel enzymes,(2) encapsulate an industrially relevant enzyme catalyst within a plant-produced microcompartment as a proof-of-concept for this engineering approach.This project will generate the proof-of-concept required to deliver breakthroughs in how we can use plants to fuel a greener, more environmentally sustainable future.

环境和工业面临的巨大压力意味着必须开发更环保的方法来生产社会所需的材料和产品。植物提供了我们使用的大部分可再生产品和材料，并通过工程设计提供了巨大的机会，进一步创新其在生物经济中的用途，以实现盈利、可扩展、可持续的生产。这项工程生物学突破奖研究将设计一个基于细菌微区室的创新系统，以扩大植物作为从生物医学到生物塑料等行业的生物工厂的潜力。其主要目标是：（1）在植物内安装细菌微区室外壳作为支架封装新型酶，(2) 将工业相关的酶催化剂封装在植物生产的微室中，作为该工程方法的概念验证。该项目将产生我们需要进行概念验证，以在如何利用植物来推动更绿色、更环境可持续的未来方面取得突破。