Repurposing trypanocidal drugs to tackle amoebic gill disease in Atlantic Salmon

重新利用杀锥虫药物来解决大西洋鲑鱼的阿米巴鳃病

• 批准号: BB/T016280/1
• 负责人: Martin Llewellyn
• 金额: $ 57.22万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FT016280%2F1
• 关键词: Repurposing; trypanocidal; drugs; tackle; amoebic

Amoebic gill disease (AGD), caused by Neoparamoeba perurans, is as a major disease in salmonid aquaculture. Treatment options are currently extremely limited. Using an existing state-of the-art drug discovery pipeline at the University of Glasgow, we propose to test the potency of existing licensed and experimental drugs used against the kinetoplastid diseases (Chagas Disease, Sleeping Sickness, Leishmania) for activity against N. perurans in vitro in Scotland prior to in vivo testing of the drug candidates at a unique trial site in Ireland. Crucially N. perurans has an endosymbiotic kinetoplastid (a kinetoplastid living inside every N. perurans cell) on which it relies for essential metabolic processes. Working on the hypothesis that killing the endosymbiont will lead to death of its host, our approach promises to deliver new drugs to address an intractable problem in aquaculture. In doing so it may even drive the costs of these drugs down for medical and veterinary applications in the tropics.

阿米巴鳃病（AGD）是由秘鲁新帕拉米巴引起的，是鲑鱼养殖业的主要疾病。目前的治疗选择极其有限。利用格拉斯哥大学现有的最先进的药物发现管道，我们建议测试现有许可和实验药物用于对抗动质体疾病（恰加斯病、昏睡病、利什曼原虫）的功效，以对抗 N. perurans 的活性在爱尔兰一个独特的试验地点对候选药物进行体内测试之前，先在苏格兰进行体外测试。至关重要的是，N. perurans 具有内共生动质体（一种生活在每个 N. perurans 细胞内的动质体），它依赖于内共生动质体来进行基本的代谢过程。基于杀死内共生体将导致其宿主死亡的假设，我们的方法有望提供新药物来解决水产养殖中的棘手问题。这样做甚至可能会降低这些药物在热带地区的医疗和兽医应用的成本。

项目成果

Additional file 1 of Links between host genetics, metabolism, gut microbiome and amoebic gill disease (AGD) in Atlantic salmon

大西洋鲑鱼宿主遗传学、新陈代谢、肠道微生物组和阿米巴鳃病 (AGD) 之间的联系的附加文件 1

• DOI: http://dx.10.6084/m9.figshare.21130030
• 发表时间: 2022
• 作者: Schaal P

Towards an in situ non-lethal rapid test to accurately detect the presence of the nematode parasite, Anguillicoloides crassus, in European eel, Anguilla anguilla.

旨在进行原位非致命快速测试，以准确检测欧洲鳗鲡中是否存在线虫寄生虫 Anguillicoloides crassus。

• DOI: http://dx.10.1017/s0031182021002146
• 发表时间: 2022
• 期刊: Parasitology
• 影响因子: 2.4
• 作者: De Noia M

Links between host genetics, metabolism, gut microbiome and amoebic gill disease (AGD) in Atlantic salmon.

大西洋鲑鱼宿主遗传学、新陈代谢、肠道微生物组和阿米巴鳃病 (AGD) 之间的联系。

• DOI: http://dx.10.1186/s42523-022-00203-x
• 发表时间: 2022
• 期刊: Animal microbiome
• 影响因子: 4.7
• 作者: Schaal P

Additional file 2 of Links between host genetics, metabolism, gut microbiome and amoebic gill disease (AGD) in Atlantic salmon

大西洋鲑鱼宿主遗传学、新陈代谢、肠道微生物组和阿米巴鳃病 (AGD) 之间的联系的附加文件 2

• DOI: http://dx.10.6084/m9.figshare.21130031
• 发表时间: 2022
• 作者: Schaal P