SYNTHESIS OF NOVEL BIOLOGICALLY ACTIVE NATURAL PRODUCTS

新型生物活性天然产物的合成

• 批准号: 3278052
• 负责人: ROBERT K BOECKMAN
• 金额: $ 9.73万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-09-15 至 1990-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3278052
• 关键词: antineoplastics; chemical structure function; cycloalkene; drug design /synthesis /production; sesquiterpenes

The objectives are to develop general protocols for the synthesis of three different classes of naturally occurring compounds, Eremantholide A, Saudin, and Ginkgolide A, each of which possesses interesting biological activity and which constitute a lead in a different therapeutic area, namely cancer, diabetes, and cardiovascular disease, asthma and stroke, respectively. The syntheses have been planned with the idea that simpler analog structures will become available during our studies to assist in the development of structure activity relationships in these unique classes of compounds. Our studies will explore new strategies and new applications and methods for creation of contiguous quaternary centers, closure of medium rings, and the construction of hetero propellane systems. The problems posed by these densely functionalized cage and bridged ring structures present considerable challenges for contemporary synthetic organic chemistry.

目的是为合成三个的一般协议开发一般协议 不同类别的天然化合物，Eremantholide A， 沙特和银葡萄剂A，每个A都有有趣的生物学 活动和构成不同治疗区域的铅 即癌症，糖尿病和心血管疾病，哮喘和中风， 分别。 综合已经计划了更简单的类似物的想法 在我们的研究期间，结构将有助于协助 在这些独特的类别中的结构活动关系的发展 化合物。 我们的研究将探索新的策略以及新的应用和方法 为了建立连续的四级中心，中等环的闭合和 杂种丙烷系统的构建。 这些提出的问题 存在密集的功能化笼子和桥接环结构 当代合成有机化学面临的巨大挑战。