The contribution of capsular and subcapsular progenitor cells in homeostatic adrenal cortex self-renewal and zonal-specific remodelling.

被膜和被膜下祖细胞在稳态肾上腺皮质自我更新和区域特异性重塑中的贡献。

• 批准号: BB/V007246/1
• 负责人: Leonardo Guasti
• 金额: $ 59.91万
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FV007246%2F1
• 关键词: contribution; capsular; subcapsular; progenitor; cells

The onset of menopause in women, the decrease in testosterone secretion in men after the age of 40 and the decrease in production of growth hormone from the brain are well-recognised biological changes affecting our endocrine system as we age. The adrenal glands are two small organs located on top of the kidneys. The outer part of each gland, called the adrenal cortex, is essential for life, as it is the main site of production of steroid hormones. These steroid hormones affect carbohydrate metabolism and control the stress response, control blood volume and salt balance, and influence blood pressure.The adrenal cortex "reproduces itself" over time (a process called self-renewal), and a group of cells (called stem cells) which we have identified in the outermost layers of the gland are responsible for generating new steroid-producing cells throughout our lifetime. The aging adrenal is a poorly investigated area, despite the importance of the gland in human health and disease. Even less, the contribution of stem cells to the generation of new hormone-producing cells during our lifetime is entirely unknown. With this proposal we aim at determining differences in the ability of adrenal stem cells to make new steroid-producing cells between young and adults, males and females, with a particular emphasis on cells which produce the hormones aldosterone and corticosterone.

女性进入更年期、男性 40 岁后睾酮分泌减少以及大脑生长激素分泌减少，这些都是随着年龄增长影响内分泌系统的生物变化。肾上腺是位于肾脏顶部的两个小器官。每个腺体的外部称为肾上腺皮质，对于生命至关重要，因为它是产生类固醇激素的主要场所。这些类固醇激素影响碳水化合物代谢并控制应激反应，控制血容量和盐平衡，并影响血压。肾上腺皮质随着时间的推移“自我复制”（这一过程称为自我更新），以及一组细胞（称为干细胞）我们在腺体最外层发现的细胞）负责在我们的一生中产生新的类固醇生成细胞。尽管肾上腺在人类健康和疾病中很重要，但衰老的肾上腺是一个研究很少的领域。更不用说，干细胞在我们一生中对新的激素产生细胞的产生的贡献是完全未知的。通过这项提议，我们的目标是确定年轻人和成人、男性和女性之间肾上腺干细胞产生新类固醇生成细胞的能力差异，特别强调生成醛固酮和皮质酮激素的细胞。

项目成果

The crosstalk between FGF21 and GH leads to weakened GH receptor signaling and IGF1 expression and is associated with growth failure in very preterm infants.

• DOI: 10.3389/fendo.2023.1105602
• 发表时间: 2023
• 期刊: Frontiers in endocrinology
• 影响因子: 5.2