Antigen specificity of T cells mediating suppression of immunity to porcine reproductive and respiratory syndrome virus infection and vaccination.

T 细胞的抗原特异性介导对猪繁殖与呼吸综合征病毒感染和疫苗接种的免疫抑制。

基本信息

批准号：
BB/S017291/1
负责人：
William Golde
金额：
$ 91.49万
依托单位：
Moredun Research Institute
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2019
资助国家：
英国
起止时间：
2019 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FS017291%2F1
关键词：
Antigen specificity cells mediating suppression

项目摘要

Vaccines are the most cost effective method for controlling many infectious diseases. Using vaccines also reduces the use of antibiotics and that results in less antimicrobial resistance to drugs used to treat infection. Many pathogens affect livestock species and, in the pork industry, porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important infections today. This viral disease has spread world-wide and pig farmers struggle to control the disease. There are vaccines available in the market, but the performance of these formulations is limited. Specifically, these vaccines only provide good protection against similar strains of the virus and there are two major types and many subtypes. So, protection is fairly narrow when the farmers need the vaccine to have very broad protection. We will develop tools that will allow for the design of next generation vaccines to control spread of infection even when the circulating virus is very different from the virus used to make the vaccine. We propose to develop technologies for pig research that are already available to human vaccine researchers and that allow a more accurate and informative assessment of the immune response to vaccination. Using these modern, more informative technologies will provide new and clear results to be used in the design and testing of more affordable vaccines for PRRSV. These efforts will give farmers an important tool to control a disease that causes significant economic loss and serious pain and suffering in their animals.

疫苗是控制许多传染病的最具成本效益的方法。使用疫苗还可以减少抗生素的使用，从而减少对治疗感染的药物的耐药性。许多病原体影响牲畜物种，在养猪业中，猪繁殖与呼吸综合征病毒 (PRRSV) 是当今经济上最重要的感染之一。这种病毒性疾病已在世界范围内传播，养猪户很难控制这种疾病。市场上有疫苗，但这些制剂的性能有限。具体来说，这些疫苗只能针对相似的病毒株提供良好的保护，并且有两种主要类型和许多亚型。因此，当农民需要疫苗提供非常广泛的保护时，保护范围就相当狭窄。我们将开发工具，以便设计下一代疫苗来控制感染的传播，即使正在传播的病毒与用于制造疫苗的病毒非常不同。我们建议开发用于猪研究的技术，这些技术已经可供人类疫苗研究人员使用，并且可以对疫苗接种的免疫反应进行更准确和信息更丰富的评估。使用这些信息更丰富的现代技术将提供新的、明确的结果，用于设计和测试更实惠的 PRRSV 疫苗。这些努力将为农民提供控制这种导致动物重大经济损失和严重痛苦的疾病的重要工具。