NEW SYNTHETIC METHODS USEFUL FOR CHEMOTHERAPEUTICS

适用于化疗的新合成方法

• 批准号: 3269436
• 负责人: Peter A. Beak
• 金额: $ 17.04万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-08-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3269436
• 关键词: allyl compound; amides; carbanion; carboxylation; chemical models; chemical reaction; chemotherapy; cyclopentane; drug design /synthesis /production; esters; halocarbon compound; lithium; reagent /indicator; saturated /unsaturated bonds

The goal of this work is the designed discovery, development and understanding of reactions which will substantially improve synthetic methodology. The proposed studies range from approaches which could provide new strategies for synthesis to the development of emerging methodology and the understanding of established reactions. The synthetic studies focus on the chemistry of organolithium reagents and include the formations and reactions of alpha-lithioamine synthetic equivalents, of beta-lithioamides and of lithiated aromatics. A systematic study of the structural requirements of lithiations directed to sites remote from the directing function will also be carried out. In addition, investigations of the ene reaction will be pursued. The proposed synthetic studies are applicable to the syntheses of many classes of molecules. In mechanistic work studies which will provide understanding of the mechanism of halogen-lithium exchange and of oxygen transfer reactions are proposed. These studies will provide knowledge which should be applicable to the improvement of current synthetic methodology.

这项工作的目的是设计的发现，开发和 理解反应，这将大大改善合成 方法论。拟议的研究范围从可以提供的方法 综合新兴方法和发展的新策略 对既定反应的理解。 合成研究的重点是有机锂试剂的化学和 包括α-硅烷胺合成的形成和反应 等效物，β-硫酸酰胺和岩性芳香剂。系统 研究针对现场的岩性的结构要求 还将执行远离指导功能的遥控器。此外， 将对ENE反应进行调查。提出的合成 研究适用于许多类别的分子的合成。 在机械工作研究中，将提供对 卤素锂交换和氧转移反应的机制是 建议的。这些研究将提供应适用的知识 改善当前合成方法。