BIOCHEMICAL LENS DAMAGE AND CATARACT RISK FACTORS

生物化学晶状体损伤和白内障风险因素

基本信息

批准号：
3265201
负责人：
GIOVANNI MARAINI
金额：
$ 3.69万
依托单位：
UNIVERSITA DEGLI STUDI DI PARMA
依托单位国家：
美国
项目类别：
财政年份：
1989
资助国家：
美国
起止时间：
1989-05-16 至 1991-04-30
项目状态：
已结题

项目摘要

The project is specifically designed to obtain biochemical data on the lenses of a cohort of patients undergoing surgery for age-related cataract and to correlate these data with those already acquired for the same cohort during the Italian-American case-control study (IACS1) and during the Italian-American natural history study (IACS2) on age-related cataract. Data collected in the course of the above mentioned epidemiological studies include a) cataract classification (clinical and photographic) and complete ophthalmological evaluation, b) medical and nutritional interview, c) biochemical data on plasma and on several RBC enzymes, d) identification of risk factors, and e) evaluation of the progression rate. By April 1, 1989 a certain number of these patients will have already had surgery but it is expected that the majority of them will need cataract removal within the next two or three years. Biochemical analysis will be performed on lens capsule epithelium preparations obtained after extracapsular extraction or, on a much smaller sample of lenses, on the whole lens after intracapsular extraction. Factors under investigation include epithelial enzymes, evaluation of thiamine and riboflavin status, sugar alcohols, water and ion content. By accomplishing these objectives, the study has the potential of filling the gap presently existing in our knowledge and concerning the absence of information on how biochemical changes in the lens relate to individual risk factors, nutritional status, progression rate of the disease.

该项目专门设计用于获取生物化学数据一组接受年龄相关手术的患者的镜片白内障并将这些数据与已经获得的数据相关联意大利-美国病例对照研究 (IACS1) 期间的同一队列在意大利-美国自然历史研究 (IACS2) 期间，关于年龄相关的白内障。在上述过程中收集的数据流行病学研究包括 a) 白内障分类（临床和照相）和完整的眼科评估，b）医学和营养访谈，c) 血浆和几种红细胞的生化数据酶，d) 风险因素的识别，以及 e) 评估进展率。到 1989 年 4 月 1 日，其中一定数量的患者已经接受过手术，但预计大多数他们将在未来两三年内需要摘除白内障。对晶状体囊上皮进行生化分析囊外提取后获得的制剂，或经过多次提取后获得的制剂较小的晶状体样本，囊内植入后的整个晶状体萃取。正在研究的因素包括上皮酶，评估硫胺素和核黄素状态、糖醇、水和离子含量。通过实现这些目标，该研究有可能填补我们的知识目前存在的差距以及缺乏有关晶状体生化变化如何与个体相关的信息危险因素、营养状况、疾病进展率。