FUNCTIONAL ASSESSMENT OF MACULAR DEGENERATIONS

黄斑变性的功能评估

• 批准号: 3265720
• 负责人: Michael A Sandberg
• 金额: $ 15.57万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-05-01 至 1995-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3265720
• 关键词: computer assisted diagnosis; cone cell; dark adaptation; diagnosis quality /standard; electroretinography; eye disorder diagnosis; eye fundus photography; eye laser surgery; fluorescein angiography; human age group; human subject; image processing; longitudinal human study; mathematical model; pathologic process; retina degeneration; retinal pigment epithelium; rod cell; statistics /biometry; vision disorders; vision tests; visual perception; visual photoreceptor

Patients with advanced age-related macular degeneration in one eye and early age-related macular degeneration in their fellow eye will have their fellow eye evaluated over a three year interval with computer-assisted maps of macular malfunction, Amsler grid testing, blue-cone thresholds in the fovea, and foveal cone electroretinograms. Results will be compared with the appearance of the macula in the fellow eye quantified from optically- scanned fundus photographs and fluorescein angiograms to determine to what extent changes in these macular function tests correspond with changes seen in the fundus on the same or subsequent visits and precede the development of exudative maculopathy and/or loss of visual acuity. In separate sets of patients with early stages of either age-related or juvenile macular degeneration, cone and rod dark adaptation kinetics will be assessed with long and short duration bleaches in regions of the macula outside the foveola to help determine if the retinal pigment epithelium or the photoreceptors, or both, are primarily involved, and to evaluate whether rod malfunction precedes cone malfunction in these regions. This research should provide a better understanding of pathophysiological mechanisms that may be involved in these conditions. In the case of age-related macular degeneration, macular degeneration, demonstration of the usefulness of one or more of the functional tests under study in detecting more patients with impending exudative maculopathy and loss of visual acuity may increase the number of patients who would subsequently benefit from laser therapy.

一只眼睛患有晚期年龄相关性黄斑变性的患者 他们的另一只眼睛的早期年龄相关性黄斑变性将有他们的 使用计算机辅助地图以三年为间隔对另一只眼睛进行评估 黄斑功能障碍、阿姆斯勒方格测试、蓝锥阈值 中央凹和中央凹锥体视网膜电图。 结果将与 通过光学量化对侧眼黄斑的外观 扫描眼底照片和荧光素血管造影以确定什么 这些黄斑功能测试的变化程度与所观察到的变化相对应 在相同或随后的访问中并在显影之前在眼底中 渗出性黄斑病变和/或视力丧失。 在单独的组中 患有早期年龄相关性黄斑或青少年黄斑的患者 退化、视锥细胞和视杆细胞暗适应动力学将通过以下方法进行评估 黄斑区以外区域的长时和短时漂白 中央凹以帮助确定视网膜色素上皮或 光感受器或两者都主要参与，并评估是否 在这些区域中，视杆故障先于视锥故障。 这项研究 应提供对病理生理机制的更好理解 可能涉及这些情况。 年龄相关性黄斑病变 变性，黄斑变性，证明其中之一的有用性 或更多正在研究的功能测试，以检测更多患有以下疾病的患者 即将发生的渗出性黄斑病变和视力丧失可能会增加 随后受益于激光治疗的患者数量。