A MODEL FOR CIRCADIAN RHYTHM OF IOP

眼压昼夜节律模型

• 批准号: 3259828
• 负责人: DOUGLAS S GREGORY
• 金额: $ 19.8万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-08-01 至 1988-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3259828
• 关键词: biochemistry; biological models; circadian rhythms; eye pharmacology; glaucoma; homeostasis; intraocular aqueous flow; intraocular fluid; intraocular pressure; model design /development; neural information processing; radioassay; uvea ciliary body

The studies proposed in this application are designed to 1. determine whether the circadian rhythm of IOP reflects a circadian rhythm of aqueous formation, 2. explore the neural and humoral pathways which mediate regulation of this rhythm of IOP, and 3. identify biochemical mechanisms which underlie the local, ocular mediation of the circadian rhythm of IOP in this animal model. The section on Glaucoma and Aqueous Dynamics of this department is committed to the long term goal of understanding the anatomic, physiologic and biochemical basis for regulation and maintenance of IOP and aqueous flow. The circadian rhythm of IOP represents a non-invasive technique for manipulating aqueous dynamics, and, as such, provides a "handle" for studying mechanisms involved in variation of IOP. Better understanding of these mechanisms which mediate the circadian rhythm of IOP may further our understanding of the mechanisms which maintain and regulate the steady state of IOP. IOP in humans is recognized to show a daily rhythm which can be exaggerated in glaucoma patients. This spontaneous variation of IOP in open-angle glaucoma remains one of the most important and least understood enigmas of glaucoma, and a better understanding of the mechanisms underlying this phenomenon may permit exploitation of normal physiologic mechanisms to achieve control of IOP in glaucoma patients. This animal model for the circadian rhythm of IOP may also prove to be a useful non-invasive model for evaluating potential drugs for glaucoma therapy.

本应用程序中提出的研究设计为1。 IOP的昼夜节律是否反映了水。 编队，2。探索介导的神经和体液途径 对IOP节奏的调节和3。确定生化机制 这是IOP昼夜节律的本地眼镜调解的基础 在这个动物模型中。 该部门的青光眼和水性动力学部分是 致力于理解解剖学生理的长期目标 以及对IOP和水的调节和维护的生化基础 流动。 IOP的昼夜节律代表了一种非侵入性技术 操纵水性动力，因此为“手柄”提供了一个“手柄” 研究与IOP变化有关的机制。 更好地理解 这些介导IOP昼夜节律的机制可能会进一步 了解维持和调节稳定的机制 IOP状态。 IOP在人类中被认为表现出每日节奏，这可能被夸大 在青光眼患者中。 IOP在开放角度的自发变化 青光眼仍然是最重要，最了解的谜团之一 青光眼，以及对此机制的更好理解 现象可能允许剥削正常的生理机制 在青光眼患者中控制IOP。 IOP昼夜节律的这种动物模型也可能被证明是 用于评估青光眼潜在药物的有用非侵入性模型 治疗。