Longitudinal assessment of healthy brain structure and function across the lifespan using 9.4T Magnetic Resonance Imaging

使用 9.4T 磁共振成像对整个生命周期的健康大脑结构和功能进行纵向评估

• 批准号: BB/S019162/1
• 负责人: Megan Holmes
• 金额: $ 50.97万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FS019162%2F1
• 关键词: Longitudinal; assessment; healthy; brain; structure

Live Imaging of the human and animal brain, using Magnetic Resonance Imaging, has provided a wealth of information regarding the structural and functional properties of the brain across the lifespan, and identified markers associated with disease. Such specialised imaging modalities can also inform on the mechanisms and variance within populations across development and ageing. For this research to be world leading, the highest resolution scanners are required to provide accurate details of tissue structure and composition. We have an excellent, integrated infrastructure for human and animal brain imaging, but our old, animal MRI scanner needs to be replaced and upgraded, to allow us to see smaller changes in the brain structure, function, composition and connectivity and ensure our translational research remains world class.

使用磁共振成像对人类和动物大脑进行实时成像，提供了有关整个生命周期中大脑结构和功能特性的大量信息，并确定了与疾病相关的标记。这种专门的成像方式还可以了解人群在发育和衰老过程中的机制和差异。为了使这项研究处于世界领先地位，需要最高分辨率的扫描仪来提供组织结构和成分的准确细节。我们拥有优秀的人类和动物大脑成像综合基础设施，但我们旧的动物核磁共振扫描仪需要更换和升级，以使我们能够看到大脑结构、功能、组成和连接性的较小变化，并确保我们的转化研究仍然是世界一流的。

项目成果

Standardrat: A multi-center consensus protocol to enhance functional connectivity specificity in the rat brain

• DOI: 10.1101/2022.04.27.489658
• 发表时间: 2022-01-01
• 期刊: bioRxiv
• 作者: Desrosiers-Gregoire, G.;Grandjean, J.;Cardoso, B.M.
• 通讯作者: Cardoso, B.M.

18F-NaF PET/MRI for Detection of Carotid Atheroma in Acute Neurovascular Syndrome.

18F-NaF PET/MRI 用于检测急性神经血管综合征中的颈动脉粥样硬化。

• DOI: 10.1148/radiol.212283
• 发表时间: 2022
• 期刊: Radiology
• 影响因子: 19.7
• 作者: Kaczynski J

Impaired Glymphatic Function and Pulsation Alterations in a Mouse Model of Vascular Cognitive Impairment.

• DOI: 10.3389/fnagi.2021.788519
• 发表时间: 2021
• 期刊: Frontiers in aging neuroscience
• 影响因子: 4.8
• 作者: Li M;Kitamura A;Beverley J;Koudelka J;Duncombe J;Lennen R;Jansen MA;Marshall I;Platt B;Wiegand UK;Carare RO;Kalaria RN;Iliff JJ;Horsburgh K
• 通讯作者: Horsburgh K

Magnetic Resonance Imaging of Blood-Brain Barrier permeability in Dementia.

• DOI: 10.1016/j.neuroscience.2021.08.003
• 发表时间: 2021-10-15
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: Chagnot A;Barnes SR;Montagne A
• 通讯作者: Montagne A

Behavioral and Cellular Tagging in Young and in Early Cognitive Aging.

• DOI: 10.3389/fnagi.2022.809879
• 发表时间: 2022
• 期刊: Frontiers in aging neuroscience
• 影响因子: 4.8
• 作者: Gros A;Lim AWH;Hohendorf V;White N;Eckert M;McHugh TJ;Wang SH
• 通讯作者: Wang SH