A simple, genome-editable technology for inducing steeper, deeper root growth in crops

一种简单的基因组编辑技术，可诱导作物根系生长得更陡、更深

• 批准号: BB/S018824/1
• 负责人: Stefan Kepinski
• 金额: $ 25.58万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FS018824%2F1
• 关键词: simple; genome; editable; technology; inducing

This project builds directly on a BBSRC grant and PhD project that resulted in the discovery of a single, dominant point mutation in a gene regulating root growth angle causing more vertical lateral roots in the model plant Arabidopsis. This mutation is in a region of the gene that is conserved across many plant species and has the potential to be used to alter root architectures of many important crops. Root traits have a direct bearing on crop productivity via water and nutrient uptake making them an ideal high-value target for breeding/ biotechnological approaches to crop improvement. It is known that steeper roots improve water and nitrogen uptake in crop species, potentially increasing yields from lower input farming and under sub-optimal climate and soil conditions. This project will translate our findings into wheat as a proof of concept study in crops. Obtaining this proof of concept will provide vital data for patent filing and subsequent commercial exploitation.

该项目直接建立在BBSRC赠款和博士学位项目上，该项目导致在调节根生长角的基因中发现了单个主要点突变，从而导致模型植物拟南芥中更垂直的侧向根。该突变位于许多植物物种中保守的基因区域，有可能用于改变许多重要作物的根系结构。根特征通过水和养分吸收对农作物的生产力有着直接的影响，这使其成为繁殖/生物技术改善方法的理想高价值目标。众所周知，较陡的根可以改善农作物物种中的水和氮摄取，可能会增加较低的投入养殖以及在最佳的气候和土壤条件下的产量。该项目将把我们的发现转化为小麦，作为农作物概念研究的证明。获得此概念证明将为专利申请和随后的商业剥削提供重要数据。

项目成果

Auxin in Root Development.

• DOI: 10.1101/cshperspect.a039933
• 发表时间: 2021-07
• 期刊: Cold Spring Harbor perspectives in biology
• 影响因子: 7.2
• 作者: Suruchi Roychoudhry;S. Kepinski

The Analysis of Gravitropic Setpoint Angle Control in Plants.

植物向重力设定点角度控制的分析。

• DOI: 10.1007/978-1-0716-1677-2_10
• 发表时间: 2022
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Roychoudhry S