PHYSIOLOGIC STUDIES OF INTRAOCULAR PRESSURE

眼内压的生理学研究

• 批准号: 3255205
• 负责人: MARVIN L SEARS
• 金额: $ 24.46万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-01-01 至 1987-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3255205
• 关键词: biological information processing; blood aqueous barrier; cell biology; drug metabolism; eye pharmacology; glaucoma; gonadotropin releasing factor; intraocular pressure; neural information processing; ocular hypotensive; peptide hormone

The long term objective of this proposal is to learn whether humoral mediators can influence or regulate intraocular pressure in normal and/or glaucomatous eyes. Evidence from clinical and laboratory sources indicates that intraocular pressure can vary in a circadian rhythm, fall in pregnancy, and fall in response to agents administered systemically that stimulate the production of cyclic AMP in ciliary epithelia, the tissue secreting aqueous humor. The specific aim of this research is to follow up our observation that certain glycoprotein hormones, in concentrations very similar to circulating levels of hormones found in vivo can reduce intraocular pressure. Studies will be initiated with HCG. The physiologic and cellular site of action will be determined and the chemical mechanism for the reduction of intraocular pressure be determined. Additional information from other glycoproteins and analogs of these and of HCG will be used to analyze the site of the response and its biochemical mechanisms. This proposal is consistent with the program base of the N.E.I. national plan for vision research of the glaucoma panel in its study of 1) cellular mechanisms of drug action to alter rate of inflow of aqueous humor, 2) the physiology and pathophysiology of aqueous humor inflow in hypotony, and 3) the cell biology of tissues involved in aqueous humor formation. The proposal to investigate endogenous neural and humoral regulating mechanisms is one of the N.E.I. glaucoma panels program development priorities.

该提案的长期目标是了解体液是否 介质可以影响或调节正常和/或 青光眼的眼睛。 来自临床和实验室的证据表明 眼压可随昼夜节律变化， 怀孕，并因全身给药的药物而跌倒 刺激睫状上皮细胞（组织）中环磷酸腺苷的产生 分泌房水。 本研究的具体目的是跟进 我们观察到某些糖蛋白激素的浓度非常高 与体内发现的激素循环水平相似，可以降低 眼压。 研究将通过 HCG 启动。 生理学 并确定细胞作用位点和化学机制 以确定眼压的降低程度。 额外的 来自其他糖蛋白及其类似物和 HCG 的信息将 用于分析反应位点及其生化 机制。 该提案与该计划的基础一致 N.E.I.青光眼小组的国家视力研究计划在其研究中 1) 改变房水流入速率的药物作用的细胞机制 体液，2）房水流入的生理学和病理生理学 低张力，以及 3) 参与房水的组织的细胞生物学 形成。 研究内源性神经和体液的提案 调节机制是 N.E.I. 之一。青光眼面板计划 发展重点。