PARTICLE-BOUND ACROLEIN AND PULMONARY DEFENSES

颗粒结合丙烯醛和肺防御

• 批准号: 3253720
• 负责人: GEORGE J JAKAB
• 金额: $ 22.4万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3253720
• 关键词: acrolein; bactericidal immunity; carbon; chemical binding; hemagglutination test; high performance liquid chromatography; immunotoxicity; inhalation drug administration; laboratory mouse; lung disorder; particle; phagocytosis; pollutant interaction; pollution related respiratory disorder; respiratory infections; respiratory toxin; spectrometry; statistics /biometry

Aldehydes such as acrolein emitted by combustion sources are often associated with respirable sized particles. The majority of this hydrophilic vapor is absorbed in the upper respiratory tract. However, if acrolein is absorbed on respirable particles which are deposited in the distal lung, the toxic site is shifted from the upper to the lower respiratory tract. The overall goal of this proposal is to determine the mechanisms by which the acrolein-carbonaceous particle complex compromises the defenses of the lungs. The hypothesis of this application is that acrolein must be bound to the surface of a particle to exhibit pulmonary toxicity. The hypothesis of this application is based on the assumption that release of particle-bound acrolein (bioavailability) is required in order to produce the subsequent bioeffects. This aim will be accomplished through studies of specific functional parameters of lung defenses, determination of acute and long-term lung toxicity and the mechanisms that govern the toxic effects of acrolein-- particle complexes.

燃烧来源发射的丙烯醛等醛通常是 与可呼吸大小的颗粒有关。大多数 在上呼吸道中吸收亲水性蒸气。但是，如果 丙烯醛被吸收在沉积在的可呼吸颗粒上 肺远端，有毒部位从上部转移到下部 呼吸道。 该提议的总体目标是确定 丙烯醛碳质颗粒复合物损害了该防御 肺。该应用的假设是丙烯醛必须与 粒子表面表现出肺毒性。假设 该应用是基于以下假设 为了产生后续 生物效应。 这个目标将通过研究特定功能来实现 肺部防御的参数，急性和长期肺的确定 毒性和控制丙烯醛毒性作用的机制 - 粒子络合物。