ConBioChem: Continuous bio-production of commodity chemicals

ConBioChem：大宗化学品的连续生物生产

基本信息

批准号：
BB/N023773/1
负责人：
Alex Conradie
金额：
$ 200.85万
依托单位：
University of Nottingham
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FN023773%2F1
关键词：
ConBioChem Continuous bio production commodity

项目摘要

The current slump in oil prices should not lead us to ignore the fact that, in the future, an ever-increasing proportion of the fuels and chemicals, required for everything from jumbo jets to toy elephants, will need to come from renewable resources. This means a huge expansion of the fermentation industry, and the cost of the required manufacturing plant will rapidly become unaffordable. The solution is to move from performing fermentations batchwise (like manufacturing cars one at a time) to continuous processes (like an automobile production line). This major change presents a number of challenges in engineering production microbes, and in designing and controlling the industrial processes in which they operate. This project aims to produce a pipeline that will meet all of these challenges in an integrative manner. It will result in stable and robust production microbes in which there is an optimal balance between the growth of the process microorganism and formation of the industrial product that it generates. The new microbes will be exploited in new continuous processes, and process controls will be developed in which the microbe is 'rewarded' with nutrients for generating high levels of the industrial product. Such a 'control by incentives' strategy will, in itself, contribute to the stability of the production organism. The environmental impacts of the new processes will be assessed to ensure that they are cleaner and greener than the chemical processes that they are replacing. Lastly, the costs of building new factories to manufacture the chemicals will be assessed, together with the costs of operating them, to ensure that the new continuous bio-manufacturing processes will be profitable for UK companies.

当前油价暴跌不应让我们忽视这样一个事实：未来，从大型喷气式飞机到玩具大象等各种产品所需的燃料和化学品中，越来越多的燃料和化学品将需要来自可再生资源。这意味着发酵工业的巨大扩张，所需制造工厂的成本将迅速变得难以承受。解决方案是从分批发酵（如一次制造一辆汽车）转向连续流程（如汽车生产线）。这一重大变化给微生物工程生产以及设计和控制微生物运行的工业过程带来了许多挑战。该项目旨在开发一条能够以综合方式应对所有这些挑战的管道。它将产生稳定而强大的生产微生物，其中工艺微生物的生长与其产生的工业产品的形成之间存在最佳平衡。新的微生物将在新的连续工艺中得到利用，并且将开发工艺控制，其中微生物将获得营养物质的“奖励”，以产生高水平的工业产品。这种“激励控制”策略本身将有助于生产有机体的稳定。我们将评估新工艺的环境影响，以确保它们比它们正在取代的化学工艺更清洁、更环保。最后，将评估建造新工厂来制造化学品的成本以及运营成本，以确保新的连续生物制造工艺将为英国公司带来利润。