Deconstructing molecular self-assembly by advanced mass spectrometry

通过先进的质谱解构分子自组装

• 批准号: DE170100677
• 负责人: Dr Nicole Rijs
• 金额: $ 27.06万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-10-22 至 2023-11-23
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE170100677
• 关键词: Deconstructing; molecular; self; assembly; advanced

This project aims to develop ion-mobility mass spectrometry methods to observe the molecular evolution of model self-assembly reactions with high temporal and structural resolution, and interrogate the intrinsic gas phase functionality of the assemblies themselves, including aggregation, inclusion and disassembly behaviours. Lack of knowledge of reaction intermediates, mechanisms and kinetics hampers the industrial potential of self-assembly to fabricate highly functional materials. This project expects to determine the critical link between the assemblies’ structure and function, and provide the rational framework to optimise and direct synthetic outcomes. This could enable Australian manufacturers to create low-energy production processes of high value commodities.

该项目旨在开发离子淌度质谱方法，以高时间和结构分辨率观察模型自组装反应的分子演化，并探究组装体本身的内在气相功能，包括聚集、包含和分解行为。对中间反应、机制和动力学的了解阻碍了自组装制造高功能材料的工业潜力，该项目期望确定组装体的结构和动力学之间的关键联系。功能，并提供合理的框架来优化和指导合成结果，这可以使澳大利亚制造商创造高价值商品的低能耗生产流程。