POLYAMINE INHIBITORS TARGETING MICROSPORIDIA

针对微孢子虫的多胺抑制剂

• 批准号: 2887455
• 负责人: MURRAY WITTNER
• 金额: $ 33.36万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2887455
• 关键词: Microsporidia; antiprotozoal agents; drug design /synthesis /production; human tissue; microorganism metabolism; molecular cloning; polyamines; trout /salmon

DESCRIPTION: (Adapted from Applicant's Abstract) The investigators have initiated studies to elucidate the polyamine metabolic pathways of the microsporidia as potential targets for drug design. Preliminary in vitro data suggests that inhibition of this pathway inhibits microsporidial replication. The purpose of this proposal is to investigate the usefulness of drugs designed to inhibit this pathway and thus develop a target for effective treatment of microsporidian infections in man.

描述：（改编自申请人的摘要）研究人员已经 发起了研究以阐明多胺代谢途径 微孢子虫作为药物设计的潜在靶标。 初步体外实验 数据表明，抑制该途径会抑制微孢子虫 复制。 该提案的目的是调查其有用性 旨在抑制该途径的药物，从而开发出一个靶点 有效治疗人类微孢子虫感染。