ORAL DISEASES-HIV INFECTION IN MINORITIES-FOLLOW-UP STDY

口腔疾病 - 少数族裔 HIV 感染 - 随访研究

• 批准号: 3223620
• 负责人: ARTHUR QUART
• 金额: $ 30.05万
• 依托单位: MONTEFIORE MEDICAL CENTER (BRONX, NY)
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-03-15 至 1994-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3223620
• 关键词: AIDS; African American; Candida; HIV infections; Herpes simplex disease; Hispanic Americans; Kaposi's sarcoma; aphthous stomatitis; candidiasis; dental caries; dental deposit removal; gingivitis; human immunodeficiency virus 1; human subject; human therapy evaluation; intravenous drug abuse; longitudinal human study; medical complication; methadone; microorganism disease chemotherapy; oral leukoplakia; oral pharyngeal surgery; periodontitis; root canal therapy; tooth extraction; urban area

Oral lesions are common in patients with AIDS and HIV infection. They are responsible for substantial morbidity and may represent the first clinical manifestation of HIV infection. Their appearance and clinical characteristics have been almost exclusively described in clinical series among homosexual and bisexual men with HIV infection, largely of middle class background. The demography of HIV infection is shifting towards persons who have used intravenous drugs and their sexual partners, largely of low socioeconomic status and minority background. There are few studies of oral disease in this central population in the AIDS epidemic. We propose to study the oral manifestations of HIV infection in a heterosexual, largely minority IVDU population in the Bronx, N.Y. The population will consist of 250 HIV seropositive men and women and 100 HIV seronegative controls in a methadone maintenance program, who are enrolled in an ongoing study of the natural history of HIV infection. Extensive behavioral, clinical and laboratory data are available for this population. The study will provide a systematic population-based comparison of the prevalance and incidence of oral, periodontal and dental lesions in HIV seropositive and negative individuals. The study will also provide information on the response to treatment of oral and dental conditions and investigate possible differences between HIV seronegatives and seroposi ves.

口腔病变在艾滋病和艾滋病毒感染者中很常见。 他们 造成重大发病率并可能代表第一个 HIV感染的临床表现。 它们的外观和临床 特征几乎完全在临床系列中描述 在感染艾滋病毒的同性恋和双性恋男性中，大部分是中产阶级 班级背景。 艾滋病毒感染者的人口结构正在向使用过艾滋病毒的人转变 静脉吸毒者及其性伴侣，大多社会经济地位较低 地位和少数民族背景。 关于口腔疾病的研究还很少 在艾滋病流行的这个中心人群中。 我们建议研究 HIV 感染的口腔表现 纽约州布朗克斯区的异性恋者，主要是少数 IVDU 人群。 人口将包括 250 名艾滋病毒血清阳性男性和女性以及 100 名艾滋病毒感染者 美沙酮维持计划中的血清阴性对照，他们是 参加了一项正在进行的艾滋病毒感染自然史研究。 为此可以获得大量的行为、临床和实验室数据 人口。 该研究将提供基于人群的系统比较 HIV 口腔、牙周和牙齿病变的患病率和发生率 血清阳性和阴性个体。 该研究还将提供 有关口腔和牙齿疾病治疗反应的信息 并调查 HIV 血清阴性和血清阳性之间可能存在的差异 ves。