EPIDEMIOLOGY OF KSHV AND AIDS-RELATED KAPOSIS SARCOMA

KSHV 和艾滋病相关卡波西斯肉瘤的流行病学

• 批准号: 2769985
• 负责人: LISA P JACOBSON
• 金额: $ 22.3万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2769985
• 关键词: Kaposi's sarcoma; clinical research; human herpesvirus 8; human immunodeficiency virus 1; human subject; male; neoplasm /cancer epidemiology; sex behavior; substance abuse related disorder; virus related neoplasm /cancer

DESCRIPTION (adapted from the Abstract): The goal of this study is to define the epidemiology of HIV-1 related Kaposi's sarcoma (KS) as it relates to the putative causal agent, KS herpes virus (KSHV). A proposed historical cohort study nested within the Multicenter AIDS Cohort Study (MACS), a longitudinal prospective study of the natural history of HIV-1 infection in homosexual/ bisexual men, will address these specific aims: (1) determine the prevalence and incidence of KSHV infection in this population; (2) determine the KSHV route of transmission and the concordance of characteristics associated with the virus to risk factors for KS; (3) determine rates and biological markers of progression to KS among KSHV seropositive, HIV-1 infected homosexual men and factors which may modify disease progression; (4) examine the effect of anti-retroviral and anti-herpes treatments on KS disease progression in the presence of KSHV infection; and (5) examine the health effects of KSHV in the absence of HIV-1 and the effect of KSHV on HIV-1 progression independent of its role in KS disease. Behaviors to be examined as risk factors include numbers of male sexual partners and types of sexual activities (e.g., anal/genital intercourse, anal/oral intercourse, genital/oral intercourse) and recreational drug use (e.g., nitrite inhalants). Host characteristics including age, race and immune status will be examined as effect modifiers for viral acquisition and disease progression. The effects of other environmental factors such as geographic location and co-infections will be studied, also. KSHV serological testing will be performed on selected visits for 414 HIV-1 seroconverters with known dates of seroconversion within 1 year and a stratified random sample of 400 HIV-1 seroprevalent and 100 seronegative men. KSHV seroprevalence also will be determined in a sample of injecting drug users from a cohort study with protocols similar as the MACS. Establishing the epidemiology of the KSHV, consistent with principles of causality, will provide direction for developing behavioral and therapeutic interventions against the development of KS and will guide virological and biological investigations determining the pathogenesis of this disease.

描述（改编自摘要）：本研究的目标是 定义 HIV-1 相关卡波西肉瘤 (KS) 的流行病学 假定的致病因子 KS 疱疹病毒 (KSHV)。 拟议的历史 队列研究嵌套在多中心艾滋病队列研究 (MACS) 中，这是一项 HIV-1感染自然史的纵向前瞻性研究 同性恋/双性恋男性将解决这些具体目标：(1) 确定 该人群中 KSHV 感染的患病率和发病率； (2) 确定 KSHV 的传播途径和一致性 与病毒相关的特征与 KS 的危险因素； (3) 确定 KSHV 中进展为 KS 的比率和生物标志物 血清反应呈阳性、HIV-1 感染的同性恋男性以及可能改变的因素 疾病进展； (4) 检测抗逆转录病毒的效果 在存在 KSHV 的情况下，抗疱疹治疗对 KS 疾病进展的影响 感染; (5) 在没有以下情况的情况下检查 KSHV 对健康的影响 HIV-1 和 KSHV 对 HIV-1 进展的影响独立于其在 KS病。 作为危险因素进行检查的行为包括 男性性伴侣和性活动类型（例如肛门/生殖器） 性交、肛交/口交、生殖器/口交）和 使用娱乐性药物（例如亚硝酸盐吸入剂）。 主机特点 包括年龄、种族和免疫状况将作为效果调节剂进行检查 用于病毒获得和疾病进展。 其他的影响 地理位置和合并感染等环境因素将 也研究过， KSHV 血清学检测将对选定的 拜访 414 名已知血清转化日期的 HIV-1 血清转化者 一年内对 400 名 HIV-1 血清流行者进行分层随机抽样， 100 名血清阴性男性。 KSHV 血清流行率也将在 来自队列研究的注射吸毒者样本，其方案类似于 MACS。 建立 KSHV 的流行病学，与 因果关系原则将为发展行为提供方向 以及针对 KS 发展的治疗干预措施，并将指导 确定发病机制的病毒学和生物学研究 这种病。