15AGRITECHCAT3 Precision Breeding: Broilers from Sequence to Consequence

15AGRITECHCAT3 精准育种：肉鸡从顺序到结果

• 批准号: BB/N004728/1
• 负责人: John Hickey
• 金额: $ 157.66万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FN004728%2F1
• 关键词: 15AGRITECHCAT3; Precision; Breeding; Broilers; Sequence

In this project, we will develop a new technology we call Precision Breeding, which is based on the collection and utilization of very large quantities of sequence data, and will enable us to dramatically accelerate the rate of genetic improvement in our broiler populations. This new technology will help us deliver real improvements to broiler industry productivity and sustainability in the UK and around the world. The project involves collaboration between two world class UK partners, Aviagen Ltd, the world's leading broiler breeding company and The Roslin Institute (RI), the world's leading research centre in the application of genomics and quantitative genetics to farm animal breeding. The project requires whole genome sequencing of samples on an unprecedented scale and even though our innovative approach dramatically reduces the costs over the conventional paradigm, the risk and costs are still considerable. Sharing the costs with Innovate UK would enable us to undertake this project.

在这个项目中，我们将开发一种我们称为Precision Breeking的新技术，该技术基于收集和利用非常大量的序列数据，并使我们能够显着加速肉鸡种群的遗传改善率。这项新技术将有助于我们为英国和世界各地的肉鸡行业生产力和可持续性提供真正的改进。该项目涉及两个世界一流的英国合作伙伴Aviagen Ltd，世界领先的肉鸡育种公司和Roslin Institute（RI），这是世界领先的研究中心，用于应用基因组学和定量遗传学在农场动物繁殖中的应用。该项目需要以前所未有的规模对样品进行整个基因组测序，即使我们的创新方法大大降低了与常规范式相比的成本，但风险和成本仍然相当大。与Innovate UK分享成本将使我们能够进行该项目。

项目成果

MOESM1 of Potential of gene drives with genome editing to increase genetic gain in livestock breeding programs

MOESM1 的基因驱动与基因组编辑增加牲畜育种计划遗传增益的潜力

• DOI: 10.6084/m9.figshare.c.3666634_d1
• 发表时间: 2017
• 作者: Gonen S

MOESM5 of A hybrid method for the imputation of genomic data in livestock populations

MOESM5 家畜种群基因组数据插补的混合方法

• DOI: 10.6084/m9.figshare.c.3708046_d5
• 发表时间: 2017
• 作者: AntolA­N R

A hybrid method for the imputation of genomic data in livestock populations.

• DOI: 10.1186/s12711-017-0300-y
• 发表时间: 2017-03-03
• 期刊: Genetics, selection, evolution : GSE
• 作者: Antolín R;Nettelblad C;Gorjanc G;Money D;Hickey JM
• 通讯作者: Hickey JM

Effect of manipulating recombination rates on response to selection in livestock breeding programs.

• DOI: 10.1186/s12711-016-0221-1
• 发表时间: 2016-06-22
• 期刊: Genetics, selection, evolution : GSE
• 作者: Battagin M;Gorjanc G;Faux AM;Johnston SE;Hickey JM
• 通讯作者: Hickey JM

Potential of gene drives with genome editing to increase genetic gain in livestock breeding programs.

• DOI: 10.1186/s12711-016-0280-3
• 发表时间: 2017-01-04
• 期刊: Genetics, selection, evolution : GSE
• 作者: Gonen S;Jenko J;Gorjanc G;Mileham AJ;Whitelaw CB;Hickey JM
• 通讯作者: Hickey JM