CORE--PHARMACOLOGY

核心--药理学

• 批准号: 6203196
• 负责人: JOHN KUHN
• 金额: $ 13.16万
• 依托单位: CTRC RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6203196
• 关键词: analytical chemistry; analytical method; antineoplastics; atomic absorption spectrometry; biomedical facility; clearance rate; computer data analysis; computer program /software; drug design /synthesis /production; drug metabolism; drug screening /evaluation; high performance liquid chromatography; neoplasm /cancer chemotherapy; neoplasm /cancer pharmacology; pharmacokinetics; training

DESCRIPTION: (Applicant's Description) The purpose of the Pharmacology Shared Resource is to provide a centralized resource to the members of the San Antonio Cancer Institute (SACI) for the design, implementation and evaluation of preclinical and clinical pharmacological studies of anti- tumor compounds or biological agents. The pharmacology core facility consists of three 600 square biological agents. The pharmacology core facility consists of three 600 square feet. molecular pharmacotherapy laboratory, located on the third floor of the UTHSC Robert F. McDermott Clinical Science Building. The facility is strategically positioned just a few blocks from the in-patient NIH designated clinical research center (RR-01346) and the out-patient (Cancer Therapy and Research Center) Phase I unit. Located one floor below the pharmacology facility is the UTHSC Imagining Center (PET, NMR) and our GLP animal toxicology facility. Each laboratory is equipped with state-of-the-art analytical equipment. Adjacent to the laboratories are common utility labs which house the large common equipment such as the dishwasher, ice machine, floor centrifuges, and a steam sterilizer. Six PC computer clones house in the laboratories support data capture, storage, data integration, as well as data analysis. The resource coordinator has 160 square feet of office space for use and secretarial support equipped with Macintosh computers for generation of reports and manuscripts. The specific aims and functions of this shared resource include the following: 1. To collaborate in the design of clinical and laboratory studies; to review all research protocols and make recommendations related to the pharmacological aspects of the studies, taking into account limitations of sample volume, assay sensitivity, equipment, personnel, time and cost. 2. To implement or develop suitable analytical methodologies under good laboratory science guidelines for the measurement of drug concentrations in biological fluids and/or tissues. 3. To perform studies in tissues, animals, or humans of the absorption, clearance, tissues distribution, metabolism and excretion and compounds after parenteral, oral or regional administration. 4. To provide pharmacokinetic data analyse through the use of both commercially available and customized computer programs, followed by a report and interpretation of the data. 5. To correlate observed biological effects with pharmacokinetic parameters. 6. To provide education and training to students, postdoctoral fellows, and investigators in the performance of preclinical/clinical pharmacology studies.

描述：（申请人的描述）药理学的目的 共享资源是为成员提供集中的资源 圣安东尼奥癌症研究所 (SACI) 负责设计、实施和 抗肿瘤药物临床前和临床药理学研究的评价 肿瘤化合物或生物制剂。药理学核心设施 由三个600平方的生物制剂组成。药理学核心 设施由三个 600 平方英尺组成。分子药物治疗 实验室，位于 UTHSC Robert F. McDermott 三楼 临床科学大楼。该设施地理位置优越， 距住院 NIH 指定临床研究中心仅几个街区 （RR-01346）和门诊（癌症治疗和研究中心）阶段 我单位。 UTHSC 位于药理学设施下方一层 成像中心（PET、NMR）和我们的 GLP 动物毒理学设施。每个 实验室配备了最先进的分析设备。 与实验室相邻的是公用设施实验室，里面有大型的 洗碗机、制冰机、落地式离心机等常见设备， 和蒸汽灭菌器。实验室内有六台 PC 克隆机 支持数据采集、存储、数据集成以及数据分析。 资源协调员拥有 160 平方英尺的办公空间供使用和 配备 Macintosh 计算机的秘书支持，用于生成 报告和手稿。 该共享资源的具体目标和功能包括 下列的： 1. 合作设计临床和实验室研究；到 审查所有研究方案并提出相关建议 考虑到研究的药理学方面的局限性 样品量、测定灵敏度、设备、人员、时间和成本。 2. 在良好的环境下实施或开发合适的分析方法 药物浓度测量实验室科学指南 在生物体液和/或组织中。 3. 在组织、动物或人体中进行吸收研究， 清除、组织分布、代谢和排泄以及化合物 胃肠外、口服或区域给药后。 4. 通过两者的使用提供药代动力学数据分析 商业上可用的和定制的计算机程序，然后是 报告和数据解释。 5. 将观察到的生物效应与药代动力学相关联 参数。 6. 为学生、博士后、 和临床前/临床药理学表现的研究人员 研究。