BEHAVIORAL GENETICS OF COCAINE AND RELATED COMPOUNDS

可卡因及相关化合物的行为遗传学

• 批准号: 3209017
• 负责人: JOHN M. CARNEY
• 金额: $ 12.95万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-02-01 至 1990-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3209017
• 关键词: apomorphine; behavioral genetics; body temperature regulation; caffeine; central nervous system stimulants; chordate locomotion; cocaine; dextroamphetamine; discrimination learning; drug tolerance; genetic strain; laboratory mouse; methylphenidate; operant conditionings; psychopharmacology

The purpose of this research is to provide a foundation for understanding the inheritance of sensitivity to the effects of cocaine and other psychomotor stimulants. The basic hypothesis is that behavioral stimulants like cocaine, amphetamine and caffeine produce their effects by initially interacting with different biochemical systems. This is most clearly demonstrated by describing the separable effects of these drugs in inbred mice and their recombinant inbred lines. The proposed studies will examine the effects of cocaine, norcocaine, methylphenidate and d-amphetamine on mouse body temperature, spontaneous locomotor activity, operant behavior and drug discrimination tasks. Both the progenitor strains (e.g. C57BL/6, DBA/2J) and recombinant inbred lines (e.g. BXD-11, BXD21, etc) will be used to study the separable or associated inheritance of sensitivity to these drug effects. Chronic administration of each of the stimulants will be studied to determine the relationship between acute effects and the magnitude of tolerance or sensitization observed.

这项研究的目的是为理解 对可卡因和其他其他影响的敏感性的遗传 精神运动兴奋剂。 基本假设是行为刺激物 像可卡因一样，苯丙胺和咖啡因最初通过 与不同的生化系统相互作用。 这是最清楚的 通过描述这些药物在近交中的可分离作用来证明 小鼠及其重组近交系。 拟议的研究将检查 可卡因，甲康卡因，甲基苯甲酸甲酯和D-苯丙胺对 小鼠体温，自发运动活动，操作行为 和毒品歧视任务。 两种祖细胞菌株（例如C57BL/6， DBA/2J）和重组近交系（例如BXD-11，BXD21等）将使用 研究对这些敏感性的可分离或相关的继承 药物影响。 每种兴奋剂的长期给药 研究以确定急性效应与 观察到的耐受性或敏化的大小。