Reaching new heights in high-resolution electron microscopy

达到高分辨率电子显微镜的新高度

• 批准号: LE150100149
• 负责人: Prof Benjamin Hankamer
• 金额: $ 39.34万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE150100149
• 关键词: Reaching; new; heights; resolution; electron

High-resolution electron microscopy (EM): Direct electron detection cameras are a recent technological breakthrough delivering one of the greatest single advancements to the field of molecular cryo-EM. The aim of this project is to enable a 'first of a kind' cryo-EM platform in Australia enabling high-throughput atomic resolution protein structure determination. This will be achieved by integrating a state-of-the-art Gatan K2 Summit Direct Electron Detection camera system into the established cryo-EM facility managed by the University of Queensland node of the Australian Microscopy and Microanalysis Facility. This will offer unique and significantly improved capabilities for atomic resolution protein structure analysis, and will support a broad range of projects across the biological sciences.

高分辨率电子显微镜 (EM)：直接电子检测相机是一项最新技术突破，为分子冷冻电子显微镜领域带来了最伟大的单一进步之一。该项目的目的是在澳大利亚建立“同类首个”冷冻电镜平台，从而实现高通量原子分辨率蛋白质结构测定。这将通过将最先进的 Gatan K2 Summit 直接电子检测摄像系统集成到由澳大利亚显微镜和微分析设施昆士兰大学节点管理的冷冻电镜设施中来实现。这将为原子分辨率蛋白质结构分析提供独特且显着改进的功能，并将支持生物科学领域的广泛项目。