MODEL OF POLYDRUG ABUSE

多种药物滥用模型

基本信息

批准号：
3210785
负责人：
Donald McMillan
金额：
$ 4.37万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-05-01 至 1991-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3210785
关键词：
alcoholic beverage consumption cannabinoids combination chemotherapy drug abuse drug administration routes drug tolerance drug withdrawal experience laboratory rat nicotine operant conditionings preference stimulus generalization

项目摘要

There are conflicting opinions as to whether the use of "gateway" drugs, such as nicotine, ethanol and delta-9-tetrachydrocannabinol lead directly to the use of "harder" drugs, such as cocaine, amphetamines and opioids. Furthermore, there are few data available on the question of how the introduction of a second drug of abuse quantitatively affects the pattern of intake of a drug for which self administration is already well established. The present experiments are designed to answer such questions using a rat model of drug self-administration. Hopefully, the findings of the present experiments will provide important insights as to the emergence of polydrug abuse patterns in humans. In initial experiments, rats will be trained to consume 5% (w/v) ethanol with water freely available by using periods of limited access to a schedule of food-pellet presentation. Preliminary data show that the rats take almost all of their fluid as ethanol using this procedure. One food, water and ethanol intake stabilize, the effects of acute and chronic administration of nicotine, delta-9- tetrahydrocannabinol and cocaine will be determined. Subsequently, chronic administration of each of these drugs will be discontinued to determine the effects of their withdrawal on ethanol self administration. In another experiment, rats will be trained to self administer intravenously, cocaine, nicotine and if possible, delta-9-tetrahydrocannabinol to determine to what extent the "voluntary" use of a second drug influences ethanol self administration. subsequently, the opportunity to self administer these drugs will be discontinued to determine the effects of this type of withdrawal on ethanol self administration. In other experiments, comparisons will be made between rats with and without a history of ethanol administration in the acquisition of patterns of nicotine, cocaine and possibly delta-9- tetrahydrocannabinol self administration. These experiments should provide considerable useful information about drug interactions during the development of polydrug abuse patterns.

关于使用“网关”是否存在矛盾的观点药物，例如尼古丁，乙醇和Delta-9-tetrachydrocanbinol 直接导致使用“更难”的药物，例如可卡因，苯丙胺和阿片类药物。此外，数据很少关于如何引入第二种药物的问题滥用的数量影响摄入药物的模式哪个自我管理已经建立得很好。现在实验旨在使用老鼠回答此类问题药物自我管理模型。希望，目前的实验将为有关人类滥用多药的滥用模式的出现。初始实验，将训练大鼠消耗5％（w/v）乙醇通过使用有限的访问时期，可以免费获得水食品表演的时间表。初步数据显示大鼠使用此将几乎所有的液体作为乙醇使用程序。一种食物，水和乙醇摄入稳定，急性和长期给药尼古丁的影响，delta-9-- 将确定四氢大麻酚和可卡因。随后，每种药物的长期给药将被停止确定其撤回的影响乙醇自我管理。在另一个实验中，大鼠将是接受静脉注射的自我管理，可卡因，尼古丁，如果可能，delta-9-四氢大麻酚来确定什么第二种药物的“自愿”使用会影响乙醇自我管理。随后，自我的机会管理这些药物将被终止以确定这种戒断对乙醇自我管理的影响。在其他实验中，将在大鼠之间进行比较并且没有乙醇管理的历史尼古丁，可卡因和可能的delta-9-模式四氢大麻醇自我管理。这些实验应该提供有关药物的大量有用信息多毒滥用模式的发展过程中的相互作用。