RELATIONSHIP BETWEEN BLOOD AND TISSUE MICRONUTRIENT

血液和组织微量营养素之间的关系

• 批准号: 3196218
• 负责人: YEI-MEI PENG
• 金额: $ 18.51万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-03-15 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3196218
• 关键词: alcoholism /alcohol abuse; cancer prevention; cancer risk; carcinogenesis inhibitor; carotene; carotenoids; cervix; cervix neoplasms; female; high performance liquid chromatography; human subject; human tissue; mouth neoplasms; neoplasm /cancer nutrition therapy; nutrient bioavailability; nutrition aspect of cancer; nutrition related tag; oral mucosa; preneoplastic state; retinoids; skin; skin neoplasms; tobacco abuse; tocopherols; vitamin metabolism; vitamin therapy

The accumulated epidemiologic and laboratory findings have suggested that some micronutrients may inhibit or prevent the process of carcinogenesis. Since these micronutrients may exert their actions at specific tissue sites, adequate target tissue concentration of the micronutrient may be critical for the prevention of cancer and/or precancerous conditions. In order to define the role of micronutrients in cancer prevention, it is, therefore, important to study the micronutrient content of various tissues in humans, especially those with normal, premalignant lesions, and cancers. In the proposed study, we will determine the content of various micronutrients, including vitamin A, beta-carotene, lycopene, and vitamin E, in plasma, buccal mucosal cells, skin, and cervical tissues of normal individuals, subjects at high risk, and cancer patients. We will also compare the difference in micronutrient content between normal, precancerous, and cancerous tissues of same cancer patient as well as between cancerous tissues from cancer patients and normal tissues from matched controls. Because tissues other than blood and buccal mucosal cells are difficult to obtain in humans, we will, therefore, investigate whether the micronutrient content of plasma and/or buccal mucosal cells can be used as an indicator for assessing the micronutrient status of other issues. This will be accomplished by investigating the relationship between the micronutrient content of these two tissues and the micronutrient content of the target tissues such as skin and cervix in cancer patients and non-cancer individuals. The analytical procedures for analysis of the above micronutrients are well established in our laboratory. An extensive quality control/quality assurance (QC/QA) program will be followed in order to assure the accuracy of the analytical data. Our laboratory has been consistently rated as one of the most accurate analytical laboratories among the participants in the National Bureau of Standards sponsored QC/QA program for analysis of vitamin A, beta-carotene, and vitamin E since 1984. Our group at the University of Arizona Cancer Center is multidisplinary and has the necessary expertise to conduct the proposed study. We plan to complete the investigations in 4 years.

累积的流行病学和实验室发现表明 某些微量营养素可能会抑制或阻止癌变过程。 由于这些微量营养素可能会在特定的组织上发挥作用 地点，微量营养素的足够目标组织浓度可能为 对于预防癌症和/或癌前状况至关重要。 在 为了定义微量营养素在癌症预防中的作用，它是 因此，重要的是研究各种组织的微量营养素含量 在人类中，尤其是那些患有正常，预先病变和癌症的人。 在拟议的研究中，我们将确定各种的内容 微量营养素，包括维生素A，β-胡萝卜素，番茄红素和维生素 E，在血浆中，正常的颊粘膜细胞，皮肤和宫颈组织 个体，高风险的受试者和癌症患者。 我们也会 比较正常，微量营养素含量的差异 同一癌症患者的癌症和癌组织以及 癌症患者的癌组织与来自正常组织的癌组织之间 匹配的控件。 因为血液和颊粘膜以外的组织 因此，在人类中很难获得细胞，因此，我们将研究 血浆和/或颊粘膜细胞的微量营养素含量是否可以 用作评估其他微量营养素状态的指标 问题。 这将通过调查关系来实现 在这两种组织的微量营养素含量和 目标组织的微量营养素含量，例如皮肤和子宫颈 癌症患者和非癌症患者。 的分析程序 对上述微量营养素的分析已在我们的 实验室。 广泛的质量控制/质量保证（QC/QA）计划 将遵循以确保分析数据的准确性。 我们的实验室一直被评为最准确的实验室之一 国家局的参与者分析实验室 标准赞助的QC/QA计划用于分析维生素A，β-胡萝卜素， 和维生素E自1984年以来。我们的亚利桑那大学癌症小组 中心是多层的，具有进行必要的专业知识来进行 拟议的研究。 我们计划在4年内完成调查。