CYCLIZATION REACTIONS CATALYZED BY TRANSITION METALS

过渡金属催化的环化反应

• 批准号: 2759799
• 负责人: EI-ICHI NEGISHI
• 金额: $ 30.08万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2759799
• 关键词: alkenes; biological products; catalyst; chemical substitution; chemical synthesis; cyclic ketone; cyclization; heavy metals; organometallic compounds; palladium; stereochemistry

The main objective of the proposed research is to provide new and innovative synthetic methods that are applicable to the efficient and selective synthases of a wide variety of complex natural products and related organic compounds including those of medicinal and biological interest through exploration and development of organotransition metal chemistry of palladium and some other Group 7 through 11 transition metals. To this end, it is essential to have reciprocally interactive research activities between basic explorations and applications to the synthesis of natural products and related target molecules. Selection of target molecules and execution of their synthesis primarily from the viewpoint mentioned above constitute the second main objective. In some select cases, efforts will be made to synthesize compounds of medicinal interest and provide their samples. This then is the third main objective of the proposed research. Both methodological development and target synthesis will be performed in the following four areas: (1) cyclic carbopalladation, (2) cyclic acylpalladation, (3) cyclic carboxypalladation, and (4) alpha-substitution of enones. The synthesis of various target compounds will be performed. As new and attractive targets become known in the literatures, some such targets will also be selected and synthesized/ This would necessitate omission of some proposed targets and/or deferment of their synthesis as well as deletion, addition and/or modification of research topics to maximize PI's research contributions within the general area of the proposed research.

拟议研究的主要目标是提供新的和 创新的合成方法，适用于高效、 多种复杂天然产物的选择性合成酶和 相关有机化合物，包括医药和生物的有机化合物 对有机过渡金属的勘探和开发产生兴趣 钯和其他一些第 7 族到第 11 族过渡金属的化学性质 金属。为此，有必要进行相互交流 基础探索与应用之间的研究活动 天然产物及相关目标分子的合成。选择 目标分子及其合成的执行主要来自 上述观点构成了第二个主要目标。在一些 选取案例，努力合成药用化合物 有兴趣并提供样品。这是第三个主要目标 拟议的研究。 方法开发和目标合成都将在 以下四个领域：（1）循环碳钯化，（2）循环 酰基钯化，(3)环状羧基钯化，和(4)α-取代 烯酮。将进行各种目标化合物的合成。作为 新的、有吸引力的目标在文献中变得众所周知，其中一些 目标也将被选择和合成/这将需要 省略一些拟议目标和/或推迟其综合 以及删除、添加和/或修改研究主题 最大限度地提高 PI 在一般领域内的研究贡献 提出的研究。