OPTIMIZATION OF ELECTRON ARC BY DYNAMIC THERAPY

通过动态疗法优化电子弧

• 批准号: 3189848
• 负责人: DENNIS D. LEAVITT
• 金额: $ 14.54万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-02-01 至 1996-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3189848
• 关键词: biomaterial compatibility; biomedical equipment safety; biopsy; breast neoplasms; breast surgery; clinical biomedical equipment; computer assisted patient care; computer simulation; drug delivery systems; heart; lung; mathematical model; model design /development; neoplasm /cancer radiation therapy; particle accelerators; patient monitoring device; phantom model; radiation dosage; radiobiology; radiodiagnosis; thermoluminescent radiation detector; thorax

Long-term complications in normal tissue lying in the treated volume can severely limit the usefulness of radiation therapy. In radiation therapy for breast cancer the complex anatomy of the chest wall, breast, and the lymphatic system draining the region necessitates large, complex treatment volumes in close proximity to vital normal tissues in the thorax particularly the heart and lungs, which are at risk for serious late effects. The overriding long term objective of this proposal is to improve methods of breast cancer radiation therapy by better confining the radiation to the tumor target volume for adjuvant and primary treatment in order to minimize long-term complications of incidentally irradiated normal tissues. The improvement we propose, electron arc therapy, rests on the physical characteristics unique to moving electron beams and the capabilities of modern medical linear accelerators which provide a selection of multiple electron beam energies, rotational capabilities, and developing computerization which will add sophisticated control to the operation, record keeping, and safety of conformational therapy. In the initial period of funding for this project a number of technical optimizations were implemented for electron arc adjuvant chest wall irradiation and 64 treated patients were studied demonstrating the efficacy for local control, excellent cosmesis, safety and superior dose-volume relationships in lung and heart as compared to tangential photon treatment. In the renewal period we propose further technical developments for optimization of adjuvant therapy, clinical documentation of the safety of the procedure by searching for evidence of pulmonary and cardiac dysfunction in asymptomatic patients treated by electron arc, and the adaptation of the technique to the treatment of the intact breast through use of a novel range shifter to deliver uniform dose throughout the entire treatment volume.

在处理体积中的正常组织的长期并发症可以 严重限制了放射治疗的有用性。在放射疗法中 对于乳腺癌，胸壁，乳房和 淋巴系统排出该区域需要大量复杂的处理 与胸腔中重要的正常组织紧密相邻的体积 特别是心脏和肺部，有严重迟到的风险 效果。该提议的长期目标是改善 通过更好地限制乳腺癌放射治疗的方法 佐剂和初级治疗的肿瘤目标体积的辐射 为了最大程度地减少偶然受照射正常的并发症 组织。我们提出的改进，电子电弧疗法，取决于 移动电子梁和 现代医疗线性加速器的功能，提供 选择多个电子束能，旋转能力和 开发计算机化，这将为 构象治疗的操作，记录保存和安全性。在 该项目的初始资金阶段有许多技术 对电子弧形辅助胸壁实施了优化 研究了辐射和64例治疗患者，证明了功效 对于本地控制，出色的化合物，安全性和优质剂量体积 与切向光子处理相比，肺和心脏的关系。 在续签时期，我们提出了进一步的技术发展 优化辅助治疗，安全性的临床文件 通过寻找肺和心脏的证据来进行该程序 通过电子弧治疗的无症状患者的功能障碍， 通过该技术适应完好的乳房的治疗 使用新型范围变速杆在整个过程中输送均匀剂量 治疗量。