RESPONSE OF SPINAL CORD TO LOW RADIATION DOSES

脊髓对低辐射剂量的反应

• 批准号: 3187719
• 负责人: H Rodney Withers
• 金额: $ 31.4万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-01-01 至 1992-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3187719
• 关键词: disease /disorder model; guinea pigs; histopathology; laboratory rat; myelinopathy; neoplasm /cancer radiation therapy; radiation dosage; radiobiology; spinal cord injury

The radiation dose response characteristics of the spinal cord will be investigated for dose fractionation regimens using fractional doses between 1 and 4 Gy. These doses are relevant not only to standard radiotherapy but also to increasingly-used hyperfractionated and accelerated regimens which employ multiple smaller-than-standard doses per day. Myelopathy is the worst complication of radiotherapy but the fractionated dose response in the 1-4 Gy range is almost completely undocumented. Available data are inadequate for clinical application. The interval between dose fractions is also important since some data suggest that repair of sublethal damage is incomplete at 6 hours and may continue for longer than 12 hours. If significant repair occurs after 6-8

脊髓的辐射剂量反应特征将是 研究了使用分数剂量之间的剂量分馏方案 1和4 Gy。 这些剂量不仅与标准放疗有关，而且与 也是越来越多种使用的高分流和加速方案 每天采用多个标准剂量的小剂量。 骨髓病是 放疗最严重的并发症，但分离剂量反应 1-4 GY范围几乎完全没有证件。 可用数据是 临床应用不足。 剂量分数之间的间隔也很重要，因为某些数据 表明修复余生的损害在6小时时是不完整的，可能 持续超过12个小时。 如果在6-8之后发生重大维修

项目成果

Late effects of radiation on the lumbar spinal cord of guinea pigs: re-treatment tolerance.

辐射对豚鼠腰脊髓的后期影响：再治疗耐受性。

• DOI: 10.1016/0360-3016(93)90282-z
• 发表时间: 1993
• 期刊: International journal of radiation oncology, biology, physics
• 作者: Mason,KA;Withers,HR;Chiang,CS
• 通讯作者: Chiang,CS