PHYSIOLOGICAL FACTORS IN HYPERTHERMIA

热疗的生理因素

• 批准号: 3186661
• 负责人: Chang Won Song
• 金额: $ 25.99万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-01-01 至 1996-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3186661
• 关键词: adenocarcinoma; blood flow measurement; combination chemotherapy; disease /disorder model; drug delivery systems; flavones; hydralazine; interleukin 1; laboratory rat; neoplasm /cancer blood supply; neoplasm /cancer thermotherapy; nitroferricyanide; nutrition aspect of cancer; thermostability; vasoactive agent

Blood circulation plays a cardinal role in heat-induced tissue damage since tissue temperature during heating and intratissue environment factors which affect thermal damage, such as pH and nutritional supply, are closely related to blood flow. The blood flow itself is markedly altered by heat, and thus how the blood flow is changed by heat directly dictates how the tissues are damaged by heat. The heat-induced changes in blood flow in the skin and muscle have been well documented. In contrast, little is known about the effects of heat on the blood flow in other normal tissues, particularly in internal organs. The first aim of the present proposal is to elucidate the effects of heat on the blood flow in major internal organs of rats. It has recently been demonstrated that the blood circulatory system adapts to heat-stress so that second and subsequent heatings are less effective than the first heating in changing the blood flow. Circumstantial evidence suggests that such vascular adaptation is due, at least in part, to development of vascular thermotolerance in the vessel walls. The second aim of this proposal is to obtain insight into the kinetics and magnitude of vascular thermotolerance in the normal tissues and R3230 Ac adenocarcinoma of rats. It has been suggested that tumor blood flow might be selectively reduced, and thus be preferentially heated in hyperthermia by using vasoactive compounds. The third aim is to continue our study on the change sin blood flow in various normal tissues and in R3230 Ac tumors grown in different sites by various vasoactive agents such as hydralazine, nitroprusside, flavone acetic acid (FAA) and Interleukin-1 (IL-1). We will then investigate the combined effects of heat and drugs on blood flow in normal tissues and tumors. The proposed studies using animal models would provide important information for the effective use of hyperthermia in the control of human cancer.

血液循环在热诱导的组织损伤中起着基本作用，因为 加热期间的组织温度和肠内环境因素 影响热损害（例如pH和营养供应）紧密 与血流有关。 血流本身会因热量明显改变， 因此，如何通过热量改变血液的流动直接决定了 组织被热量损坏。 热诱导的皮肤和肌肉血流的变化已经 据记录。 相比之下，对热的影响知之甚少 其他正常组织中的血液流动，尤其是内部器官。 本提案的第一个目的是阐明热量的影响 大鼠主要内脏器官的血流。 最近已证明血液循环系统适应 要加热压力，以使第二和随后的加热效率较低 比改变血流的第一个加热。 旁证 表明这种血管适应至少部分是由于 血管壁中血管耐热的发展。 第二个 该提议的目的是了解动力学和大小 正常组织中的血管耐糖和R3230 AC 大鼠腺癌。 有人提出，肿瘤血流可能有选择地降低， 因此，使用血管活性优先在热疗中加热 化合物。 第三个目的是继续我们对变化罪的研究 在各种正常组织和R3230 AC肿瘤中流动 各种血管活性剂的位置，例如氢吡嗪，硝普雷斯德， 黄酮乙酸（FAA）和白介素-1（IL-1）。 然后我们会 研究热和药物对正常血流的综合作用 组织和肿瘤。 提出的使用动物模型的研究将提供重要的 有效使用热疗控制人类的信息 癌症。