Reactive Oxygen Species, metabolic by-products of mitochondrial respiration, as conserved regulators of synapse growth and neuronal homeostasis.

活性氧，线粒体呼吸的代谢副产物，作为突触生长和神经元稳态的保守调节剂。

• 批准号: BB/M002322/1
• 负责人: Sean Sweeney
• 金额: $ 26.55万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FM002322%2F1
• 关键词: Reactive; Oxygen; Species; metabolic; products

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前，GtR 中尚未提供所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但可能是因为它包含个人详细信息等敏感信息。

项目成果

JNK signalling regulates antioxidant responses in neurons.

• DOI: 10.1016/j.redox.2020.101712
• 发表时间: 2020-10
• 期刊: Redox biology
• 影响因子: 11.4
• 作者: Ugbode C;Garnham N;Fort-Aznar L;Evans GJO;Chawla S;Sweeney ST
• 通讯作者: Sweeney ST

Yeast NDI1 reconfigures neuronal metabolism and prevents the unfolded protein response in mitochondrial complex I deficiency.

• DOI: 10.1371/journal.pgen.1010793
• 发表时间: 2023-07
• 期刊: PLoS genetics
• 影响因子: 4.5

Lipid metabolic perturbation is an early-onset phenotype in adult spinster mutants: a Drosophila model for lysosomal storage disorders.

• DOI: 10.1091/mbc.e16-09-0674
• 发表时间: 2017-12-15
• 期刊: Molecular biology of the cell
• 影响因子: 3.3
• 作者: Hebbar S;Khandelwal A;Jayashree R;Hindle SJ;Chiang YN;Yew JY;Sweeney ST;Schwudke D
• 通讯作者: Schwudke D

Regulation of neuronal development and function by ROS.

• DOI: 10.1002/1873-3468.12972
• 发表时间: 2018-03
• 期刊: FEBS letters
• 影响因子: 3.5
• 作者: Oswald MCW;Garnham N;Sweeney ST;Landgraf M
• 通讯作者: Landgraf M

Inhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM.

• DOI: 10.1038/srep43106
• 发表时间: 2017-02-21
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Keenan S;Wetherill SJ;Ugbode CI;Chawla S;Brackenbury WJ;Evans GJ
• 通讯作者: Evans GJ