ANALGESIA, NARCOTIC ACTION, AND PAIN PERCEPTION

镇痛、麻醉作用和疼痛感知

• 批准号: 3206795
• 负责人: DAVID J MAYER
• 金额: $ 12.96万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1973
• 资助国家: 美国
• 起止时间: 1973-06-01 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3206795
• 关键词: analgesia; central nervous system; narcotics; neurotransmitters; pain threshold

Broadly stated, this research project has two goals. First, I plan to investigate behavioral, neurophysiological, neuroanatomical, and neurochemical aspects of analgesia produced by focal electrical stimulation of the brain and to compare this phenomenon to analgesia produced by morphine micro-injection. Some of the specific goals subsumed under this project include: 1) To precisely describe the neuroanatomical pathways utilized and the ultimate sites and mechanisms of analgesic action. 2) To further describe the involvement of endogenous opiate substances in analgesia resulting from certain environmental manipulations. 3) To examine the functional neurochemistry of narcotic and non-narcotic analgesia systems. 4) To examine behavioral manifestations of tolerance and physical dependence to the analgesia produced by these procedures and to relate these findings to the general problem of opiate addiction. 5) To be able to suggest new and practical treatment procedures for difficult or intractable pain syndromes in man. Secondly, I proposed to identify, employing electrophysiological techniques, brain areas with behaviorally significant involvement in pain perception. Stimulation-produced analgesia, morphine analgesia, and behavioral manipulation of pain perception will be utilized as tools to achieve this goal.

广泛地指出，该研究项目有两个目标。 首先，我打算 研究行为，神经生理，神经解剖学和神经化学 通过局灶性电刺激大脑和 将这种现象与吗啡微注射产生的镇痛作用。 该项目下包含的一些具体目标包括：1）准确 描述所用的神经解剖途径以及最终位置 镇痛作用的机制。 2）进一步描述 因某些环境而导致的镇痛中的内源性鸦片物质 操纵。 3）检查麻醉和 非麻醉镇痛系统。 4）检查的行为表现 这些程序产生的镇痛的耐受性和身体依赖性 并将这些发现与鸦片成瘾的一般问题联系起来。 5）到 能够为困难或 人类中棘手的疼痛综合征。 其次，我建议使用电生理技术来识别 大脑区域在疼痛感知中具有重要的参与。 刺激产生的镇痛，吗啡镇痛和行为操纵 痛苦感知将被用作实现这一目标的工具。