COMPOSITE CERAMIC/METAL WEAR COUPLES

复合陶瓷/金属磨损对

• 批准号: 2714949
• 负责人: ASHOK C KHANDKAR
• 金额: $ 10万
• 依托单位: SINTX TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2714949
• 关键词: bioengineering /biomedical engineering; biomaterial development /preparation; biomaterial evaluation; biomechanics; ceramics; chromium; cobalt; hip prosthesis; silicon compounds

This proposal plans to develop a silicon nitride ceramic for total joint prostheses that would articulate against a metal (Cobalt-Chromium, Co-Cr) component. This is propose in an attempt to eliminate the polyethylene- metal wear couples currently in us due to concerns of polyethylene particle induced osteolysis. In an alternate approach to eliminating PE wear debris and lowering the risk of brittle failure, a metal/ceramic couple is proposed where the acetabular liner (for a total hip replacement) is made from a silicon nitride-based ceramic for articulating against a conventional Co-Cr head. Experience with silicon nitride ceramics in other fields points to the potential for superior wear resistance in biomedical applications. Phase I will assess the mechanical properties and demonstrate reduced wear rates against Co-Cr via hip simulator tests. Phase II will include extended wear tests along with design and manufacturing process optimization. PROPOSED COMMERCIAL APPLICATION: The novel combination of an advanced ceramic liner articulating against Co-Cr heads will lead to negligible ware debris and osteolysis mediated implant failures. The proposed materials will find applications in hips, knees and others articulating joints.

该提案计划开发一种用于全关节的氮化硅陶瓷 可与金属（钴铬、钴铬）接合的假肢 成分。 提出这一建议是为了消除聚乙烯 由于对聚乙烯的担忧，目前美国的金属磨损夫妇 颗粒引起的骨溶解。消除 PE 的另一种方法 磨损碎片并降低脆性失效的风险，金属/陶瓷 夫妇建议髋臼衬垫（对于全髋关节） 替换件）由氮化硅基陶瓷制成，用于铰接 与传统的钴铬头相比。 氮化硅的经验 其他领域的陶瓷显示出卓越耐磨的潜力 生物医学应用中的耐药性。 第一阶段将评估机械 性能并证明通过髋关节相对于 Co-Cr 磨损率降低 模拟器测试。 第二阶段将包括长期磨损测试以及 设计和制造工艺优化。 拟议的商业应用： 先进陶瓷衬垫的新颖组合 钴铬磁头将导致可忽略不计的器皿碎片和介导的骨质溶解 植入失败。所提出的材料将在臀部、 膝盖和其他关节。