Midbrain hunger signalling modifies decision making under conflict

中脑饥饿信号改变冲突下的决策

• 批准号: DP240101831
• 负责人: Dr Leigh Walker
• 金额: $ 32.91万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101831
• 关键词: Midbrain; hunger; signalling; modifies; decision

Decision-making is one of the most important and fundamental biological processes executed by the mammalian brain. Environmental threats and physiological pressures, such as hunger, can influence decision-making processes skewing the risk/reward ratio, yet how the brain integrates these conflicting goals to determine action selection is unknown. This project aims to investigate brain chemistry and circuitry controlling decision making under conflict using a multidisciplinary approach combining behaviour, pharmacogenetics, and sophisticated molecular and functional profiling. The expected outcomes will advance theories regarding the neural organisation and computation of decision making under conflict.

决策是哺乳动物大脑执行的最重要和最基本的生物过程之一。环境威胁和生理压力（例如饥饿）可能会影响决策过程，从而扭曲风险/回报比，但大脑如何整合这些相互冲突的目标来确定行动选择尚不清楚。该项目旨在利用行为、药物遗传学以及复杂的分子和功能分析相结合的多学科方法，研究冲突下控制决策的大脑化学和电路。预期结果将推进有关冲突下决策的神经组织和计算的理论。