CELLULAR MANIFESTATIONS OF AGING IN RAT OLFACTORY CORTEX

大鼠嗅觉皮层衰老的细胞表现

• 批准号: 2762234
• 负责人: JOHN R LARSON
• 金额: $ 7.64万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2762234
• 关键词: AMPA receptors; NMDA receptors; action potentials; age difference; aging; brain electrical activity; electrodes; electrostimulus; evoked potentials; gamma aminobutyrate; laboratory rat; lateral olfactory area; long term potentiation; neural plasticity; neural transmission; neuroanatomy; olfactions; pyramidal cells; sensory mechanism; synaptic vesicles

The proposed studies will provide pilot data suggesting new directions for a more general program concerning the neurobiology of aging in the olfactory system. Olfactory deficits are common in humans during normal aging and in age-related disease states, such as Alzheimer's disease. Whereas at least part of these deficits may be peripheral in nature, it is likely that central mechanisms also deteriorate. Piriform cortex is the main central target of the olfactory bulb and plays a critical role in the identification and recollection of smells. The physiological operation of the piriform cortex circuit has been described in detail in normal (young), adult animals; however, there have been no reports of changes in function with aging. The present proposal addresses this issue and seeks to investigate aging effects on the cellular and synaptic physiology of piriform cortex neurons in the rat. The results of these investigations should help to explain why olfactory function declines with age and possibly suggest treatment strategies for prevention of age-associated sensory losses.

拟议的研究将提供预示新方向的试点数据 有关衰老神经生物学的更一般性计划 嗅觉系统。正常情况下，嗅觉缺陷在人类中很常见 衰老和与年龄相关的疾病，例如阿尔茨海默病。 尽管这些赤字中至少有一部分本质上可能是次要的，但 中央机制很可能也会恶化。梨状皮质是 嗅球的主要中心目标，起着至关重要的作用 在气味的识别和记忆中。 生理学 梨状皮层回路的运作已被详细描述 在正常（幼年）、成年动物中；但目前还没有任何报道 随着年龄的增长而发生的功能变化。 目前的提案解决了这个问题 问题并试图研究衰老对细胞和 大鼠梨状皮层神经元的突触生理学。结果 这些研究应该有助于解释为什么嗅觉功能 随着年龄的增长而下降，并可能建议治疗策略 预防与年龄相关的感觉丧失。