IMMUNE FUNCTION REGULATION BY THE FC PORTION OF ANTIBODY

抗体 FC 部分对免疫功能的调节

• 批准号: 3169346
• 负责人: EDWARD L. MORGAN
• 金额: $ 12.17万
• 依托单位: SCRIPPS CLINIC AND RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-07-15 至 1989-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3169346
• 关键词: B lymphocyte; T lymphocyte; antibody formation; cell cell interaction; cell mediated cytotoxicity; cellular immunity; genetic mapping; humoral immunity; immune complex; immunodeficiency; immunoglobulins; immunoregulation; leukocyte activation /transformation; monoclonal antibody; rheumatoid factor

The long-term goals of this proposal are to investigate the mechanisms by which: a) Fc fragments of immunoglobulin (Ig) activate human bone marrow-derived (B) lymphocytes, thymus-derived (T) lymphocytes, and monocytes; b) Fc fragments regulate in vitro immune responses; c) map the various biological functions associated with Fc fragments to discrete regions of the molecule. Upon determining the active sequence, peptides will be synthesized and assessed for biological activity. The observation that Fc fragments modulate in vitro humoral and cell-mediated immune responses suggests that this physiologic molecule may be useful as an immunotherapeutic agent in immunodeficency states and cancer management. In order to determine the in vivo applicability of fc fragments as an immune response modifier, it is necessary to understand how Fc fragments and Fc fragment-induced biologically active mediators interact with lymphoid cells and each other in regulating immune reactivity. A comprehensive program has been outlined to use Fc fragments as model system for human B cell activation.

该提议的长期目标是调查 这是：a）免疫球蛋白（IG）的FC片段激活人骨 骨髓来源（B）淋巴细胞，胸腺衍生（T）淋巴细胞和 单核细胞； b）FC片段调节体外免疫反应； c）映射 与FC片段相关的各种生物学功能 分子的区域。 确定活性序列后，肽 将合成并评估生物学活性。 FC碎片调节体外体液和 细胞介导的免疫反应表明该生理分子可能 在免疫缺陷状态中作为免疫治疗剂有用， 癌症管理。 为了确定FC的体内适用性 片段作为免疫反应修饰符，有必要了解如何 FC片段和FC片段引起的生物活性介体相互作用 与淋巴样细胞和彼此相互调节的免疫反应性。 一个 综合程序已概述用于使用FC片段作为模型系统 用于人B细胞激活。