ANTITUMOR AGENTS FROM MARINE ORGANISMS

来自海洋生物的抗肿瘤剂

• 批准号: 3164626
• 负责人: FRANCIS J SCHMITZ
• 金额: $ 11.26万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-08-01 至 1990-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3164626
• 关键词: Porifera; antineoplastic antibiotics; antineoplastics; carboxylate; chemical structure function; drug screening /evaluation; ethers; saltwater environment

The objectives of this research are to identify, isolate and determine the structure of cytotoxic and in vivo tumor inhibitory compounds from a variety of marine organisms. The primary sources for new compounds will be sponges, ascidians, and coelenterates. In addition, marine bacteria isolated from sponges and some other marine sources will be cultured and extracted to search for potential antitumor compounds. Isolation will be guided by activity testing provided by the National Cancer Institute using in vivo (PS) and/or in vitro (KB, P388, L1210) test systems. To the extent possible compounds will be isolated in sufficient quantities to conduct in vivo activity testing. Antitumor activity enhancement will be sought through structural modification of some of the active compounds isolated. A variety of established, modern separation techniques will be used to isolate compounds, and structures will be determined by single cystal x-ray analysis and/or conventional spectroscopic methods. The structures of chemically novel compounds obtained incidental to the primary objective will be investigated to the extent possible. The long term goal of this project is to discover clinically useful anticancer agents.

这项研究的目标是识别，隔离并确定 来自A的细胞毒性和体内肿瘤抑制化合物的结构 各种海洋生物。 新化合物的主要来源将是 海绵，沿海和腔植物。 另外，海洋细菌 从海绵和其他一些海洋来源分离的将被培养，并且 提取以寻找潜在的抗肿瘤化合物。 隔离将是 由国家癌症研究所提供的活动测试指导 体内（PS）和/或体外（KB，P388，L1210）测试系统。 在某种程度上 可能的化合物将以足够的数量进行分离以进行 体内活动测试。 将寻求抗肿瘤活性增强 通过对某些活性化合物分离的结构修饰。 各种已建立的现代分离技术将用于 分离株化合物，结构将由单个Cystal X射线​​确定 分析和/或常规光谱法。 结构 化学新颖的化合物，获得了主要目标的附带 将在可能的范围内进行调查。 该项目的长期目标是发现临床上有用 抗癌剂。

项目成果

Sesquiterpene furans and thiosesquiterpenes from the nudibranch Ceratosoma brevicaudatum.

来自裸鳃类动物 Ceratosoma brevicaudatum 的倍半萜呋喃和硫代倍半萜。

• DOI: 10.1021/np50059a007
• 发表时间: 1988
• 期刊: Journal of natural products
• 影响因子: 5.1
• 作者: Ksebati,MB;Schmitz,FJ
• 通讯作者: Schmitz,FJ

A new pathway of tumor promotion by the okadaic acid class compounds.

冈田酸类化合物促进肿瘤的新途径。

• 发表时间: 1990
• 期刊: Advances in second messenger and phosphoprotein research
• 作者: Fujiki,H;Suganuma,M;Nishiwaki,S;Yoshizawa,S;Winyar,B;Sugimura,T;Schmitz,FJ
• 通讯作者: Schmitz,FJ

Binding competition of okadaic acid derivatives to anti-okadaic acid antibody.

大田酸衍生物与抗大田酸抗体的结合竞争。

• DOI: 10.1016/0041-0101(91)90129-f
• 发表时间: 1991
• 期刊: Toxicon : official journal of the International Society on Toxinology
• 作者: Yatsunami,J;Fujiki,H;Suganuma,M;Nishiwaki,S;Ojika,M;Yamada,K;Levine,L
• 通讯作者: Levine,L

Phenotypic study of bacteria associated with the caribbean sclerosponge, Ceratoporella nicholsoni.

与加勒比海硬化海绵（Ceratoporella nicholsoni）相关的细菌的表型研究。

• DOI: 10.1128/aem.56.6.1750-1762.1990
• 发表时间: 1990
• 期刊: Applied and environmental microbiology
• 影响因子: 4.4
• 作者: Santavy,DL;Willenz,P;Colwell,RR
• 通讯作者: Colwell,RR