METAL RELEASE BY TOTAL REPLACEMENT PROSTHESES

全替换假体的金属释放

基本信息

批准号：
3159370
负责人：
Jonathan Black
金额：
$ 18.55万
依托单位：
CLEMSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1989
资助国家：
美国
起止时间：
1989-06-01 至 1992-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3159370
关键词：
X ray crystallography alloys atomic absorption spectrometry biomaterial development /preparation biomaterial interface interaction cytotoxicity electrochemistry hip prosthesis joint prosthesis laboratory rat mass spectrometry scanning electron microscopy

项目摘要

Clinical studies have shown significant release of metal bearing ionic species from total joint replacements, both acutely and in the long term. In vitro cytotoxicity and animal implantation studies suggest adverse biological roles for such released materials. However, their origin is unclear: they may be produced by uniform corrosion, or by wear and fretting during articulation or by some combination of these and other processes. A series of in vitro and in vivo studies is proposed to examine some features of metal release in the two common alloy systems in use today: cobalt-base and titanium-base. Four main experimental models are to be used: in vitro passive release, anodic release and cyclic loading and release from an in vivo rat THR. Independent experimental material parameters will include alloy composition, heat treatment and surface treatment. Analytical techniques will include atomic absorption spectroscopy (AAS), scanning electron microscopy with electron diffraction x- ray analysis (SEM/EDAX) and secondary ion mass spectroscopy (SIMS).

临床研究表明金属轴承的显着释放来自全关节置换术的离子种类，无论是急性还是在长期来看。体外细胞毒性和动物植入研究表明，此类释放的有害生物学作用材料。然而，它们的起源尚不清楚：它们可能是由均匀腐蚀或磨损和微动产生衔接或通过这些过程和其他过程的某种组合。提议进行一系列体外和体内研究来检验两种常见合金体系中金属释放的一些特征目前使用的：钴基和钛基。四个主要将使用的实验模型：体外被动释放，体内大鼠的阳极释放和循环加载和释放心率。独立实验材料参数将包括合金成分、热处理和表面处理。分析技术将包括原子吸收光谱 (AAS)，扫描电子显微镜，电子衍射 x- 射线分析 (SEM/EDAX) 和二次离子质谱（SIMS）。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Competitive binding of chromium, cobalt and nickel to serum proteins.

DOI：
10.1016/0142-9612(94)90049-3
发表时间：
1994-03
期刊：
Biomaterials
影响因子：
14
作者：
Jim Yang;Jonathan Black
通讯作者：
Jim Yang;Jonathan Black

The rat as an animal model for total hip replacement arthroplasty.

以大鼠作为全髋关节置换术的动物模型。

DOI：
10.3109/08941939509015381
发表时间：
1995
期刊：
Journal of investigative surgery : the official journal of the Academy of Surgical Research
影响因子：
0
作者：
Powers,DL;Claassen,B;Black,J
通讯作者：
Black,J

Human neutrophil response to short-term exposure to F-75 cobalt-based alloy.

人类中性粒细胞对短期接触 F-75 钴基合金的反应。