HUMAN THYROID HORMONE METABOLISM

人类甲状腺激素代谢

基本信息

批准号：
3150811
负责人：
JOHN T NICOLOFF
金额：
$ 12.41万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
1976
资助国家：
美国
起止时间：
1976-12-01 至 1988-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3150811
关键词：
drug metabolism goiter hormone metabolism hormone regulation /control mechanism human subject hypothyroidism iodination mathematical model myxedemas obesity pituitary thyroid axis radiobiology radioimmunoassay thyroid function thyrotropin thyrotropin releasing hormone thyroxine triiodothyronine

项目摘要

This proposal represents a continuation of a long-term project with the development of a coherent understanding of the factors responsible for altering thyroid hormone production, metabolism, delivery and disposal in states of thyroid hormone deficiency and excess, systemic illnesses, fasting and undernutrition in man. Particular areas of investigation include: 1) The determination of the mechanisms responsible for maintaining triiodothyronine blood levels by altering peripheral tissue thyroxine to triiodothyronine conversion in states of thyroxine deficiency or excess. 2) Evaluation of the metabolic consequences of altered circulating thyroid hormone levels which occur with fasting and undernutrition. 3) Determination of the major tissues and organs which are responsible for the in vivo production of triiodothyronine and reverse triiodothyronine from thyroxine. 4) Investigation of the humoral signals which appear responsible for altering free thyroxine levels, the efficiency of conversion of thyroxine to triiodothyronine and the inhibition of pituitary TSH release in fasting and nonthyroidal illnesses. 5) Determination of the mechanisms responsible for producing nonthyroid hormone suppressible thyroxine secretion by the thyroid gland in normal subjects and possible alterations which may occur in patients with nontoxic goiter, thyroid glandular injury resulting from X-ray therapy, and in certain subjects with obesity. Although some animal studies are proposed in this grant, the principal focus will be on human subjects with the view that unique differences in the regulatory control mechanisms for thyroid hormone metabolism occur in man.

该提案代表了一个长期项目的延续对负责因素的连贯理解改变甲状腺激素的产生，代谢，递送和处置甲状腺激素缺乏症和过度，全身性疾病的状态，人的禁食和营养不良。特定调查领域包括：1）确定负责的机制通过改变周围组织来维持三一个甲状腺素的血液水平甲状腺素缺乏状态的甲状腺素转化为三碘甲状腺素的转化或过量。 2）评估改变的代谢后果在禁食和营养不良。 3）确定主要组织和器官负责三碘甲醇的体内产生和反向甲状腺素的三碘甲醇。 4）调查体液信号似乎负责改变自由甲状腺素水平，效率将甲状腺素转化为三碘甲醇和抑制禁食和非甲状腺疾病中的垂体TSH释放。 5）确定负责产生非甲状腺的机制甲状腺正常甲状腺抑制甲状腺素的激素分泌受试者和可能发生的可能改变的患者可能发生甲状腺肿，由X射线治疗引起的甲状腺腺体损伤，某些具有肥胖症的受试者。尽管提出了一些动物研究在这笔赠款中，主要重点将放在人类主题上甲状腺的调节控制机制的独特差异激素代谢发生在人中。

项目成果

期刊论文数量（35）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Free thyroxine estimates in nonthyroidal illness: comparison of eight methods.

非甲状腺疾病中游离甲状腺素的估计：八种方法的比较。

DOI：
10.1210/jcem-52-6-1073
发表时间：
1981
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
0
作者：
Kaptein,EM;MacIntyre,SS;Weiner,JM;Spencer,CA;Nicoloff,JT
通讯作者：
Nicoloff,JT

Thyroid hormone metabolism in renal diseases.

肾脏疾病中的甲状腺激素代谢。

DOI：
10.1159/000407070
发表时间：
1982
期刊：
Contributions to nephrology
影响因子：
0
作者：
Kaptein,EM;Feinstein,EI;Massry,SG
通讯作者：
Massry,SG

Improved radioimmunoassay for human TSH.

DOI：
10.1016/0009-8981(80)90349-6
发表时间：
1980-12
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
0
作者：
C. Spencer;J. Nicoloff
通讯作者：
C. Spencer;J. Nicoloff

Thyrotropin secretion in thyrotoxic and thyroxine-treated patients: assessment by a sensitive immunoenzymometric assay.

甲状腺毒症和甲状腺素治疗患者的促甲状腺素分泌：通过敏感的免疫酶测定法进行评估。

DOI：
10.1210/jcem-63-2-349
发表时间：
1986
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
0
作者：
Spencer,CA;Lai-Rosenfeld,AO;Guttler,RB;LoPresti,J;Marcus,AO;Nimalasuriya,A;Eigen,A;Doss,RC;Green,BJ;Nicoloff,JT
通讯作者：
Nicoloff,JT

Alterations of serum reverse triiodothyronine and thyroxine kinetics in chronic renal failure: role of nutritional status, chronic illness, uremia, and hemodialysis.

慢性肾衰竭中血清逆转三碘甲状腺原氨酸和甲状腺素动力学的变化：营养状况、慢性病、尿毒症和血液透析的作用。