MENOPAUSE TRANSITION--BIOBEHAVIORAL MODELS OF SYMPTOMS

更年期过渡——症状的生物行为模型

• 批准号: 2714345
• 负责人: NANCY Fugate WOODS
• 金额: $ 48.81万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2714345
• 关键词: androgens; behavioral /social science research tag; catecholamines; clinical research; cortisol; estradiol; estrone; female; health behavior; health care service utilization; health surveys; hormone regulation /control mechanism; human middle age (35-64); human subject; longitudinal human study; menopause; menstrual cycle; neuroendocrine system; psychobiology; psychological stressor; questionnaires; sign /symptom; social behavior; urinalysis; women's health

DESCRIPTION: (Adapted from investigator's abstract) The purpose of the proposed study is to describe the natural history of the transition to menopause, integrating the endocrine changes of the menopausal transition with features of the social context in which they occur. Perceived stress, ovarian function, physiologic stress arousal indicators (cortisol and catecholamines, adrenal androgens) will be studied in relation to symptoms and symptom management strategies. Socialization, personal factors, health behaviors and health status will be studied as they modify the relationships between perceived stress, ovarian function, stress arousal hormones, symptoms and symptom management strategies. The proposed research will involve 150 women who have participated in an ongoing longitudinal study of midlife (Seattle Midlife Women's Health Study) from 1990 to 1995. Women will participate in an annual in-home interview including measures of health status and a health history update, keep a daily bleeding calendar, provide monthly early am urine specimens for analysis for ovarian steroids (estradiol, estrone, testosterone), adrenal androgens (DHA and DHAS), cortisol and catecholamines. Women will also complete a health update annually that includes selected measures of perceived stress, personal factors, socialization, health status changes, health behaviors (Food Frequency Questionnaire, exercise questionnaire, smoking and alcohol use questions) and use of health services for symptom management. The findings of this study will contribute to an integrative understanding of how biological changes of the menopausal transition and the context in which they occur relate to symptoms that cause distress and influence women's use of health services during midlife.

描述：（改编自研究者的摘要） 拟议的研究是为了描述过渡到的自然历史 更年期，整合更年期过渡期的内分泌变化 以及它们发生的社会背景的特征。 感受到的压力， 卵巢功能、生理应激唤醒指标（皮质醇和 将研究儿茶酚胺、肾上腺雄激素）与症状的关系 和症状管理策略。 社会化、个人因素、健康 当行为和健康状况改变关系时，将对其进行研究 感知压力、卵巢功能、压力唤醒激素之间， 症状和症状管理策略。 拟议的研究将 150 名女性参与了一项正在进行的纵向研究 1990 年至 1995 年的中年（西雅图中年妇女健康研究）。 女性 将参加年度家庭访谈，包括健康指标 状态和健康史更新，保留每日出血日历，提供 每月清晨尿液样本用于分析卵巢类固醇 （雌二醇、雌酮、睾酮）、肾上腺雄激素（DHA 和 DHAS）、 皮质醇和儿茶酚胺。 女性还将完成健康更新 每年，其中包括选定的感知压力、个人 因素、社会化、健康状况变化、健康行为（食物 频率问卷、运动问卷、吸烟和饮酒 问题）以及利用卫生服务进行症状管理。 研究结果 这项研究将有助于全面理解如何 更年期过渡的生物学变化及其背景 它们的发生与引起痛苦并影响女性使用的症状有关 中年期间的健康服务。