MOLECULAR STUDIES OF SWITCHING IN CANDIDA ALBICANS

白色念珠菌转换的分子研究

• 批准号: 3138604
• 负责人: JAMES B HICKS
• 金额: $ 21.53万
• 依托单位: SCRIPPS CLINIC AND RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3138604
• 关键词: Candida albicans; antibody specificity; cell type; cytogenetics; density gradient ultracentrifugation; fungal genetics; gel electrophoresis; gene complementation; gene mutation; genetic library; genetic markers; genetic recombination; genetic strain; genetic transcription; molecular cloning; molecular genetics; morphology; nucleic acid sequence; plasmids; virulence; Candida albicans; antibody specificity; cell type; cytogenetics; density gradient ultracentrifugation; fungal genetics; gel electrophoresis; gene complementation; gene mutation; genetic library; genetic markers; genetic recombination; genetic strain; genetic transcription; molecular cloning; molecular genetics; morphology; nucleic acid sequence; plasmids; virulence

The dimorphic yeast, Candida albicans is both a human pathogen and a commensal organism, occupying many niches in and on the human body. Discovery of new metastable morphological states of the organism has led to the hypothesis that its polymorphic nature is related to pathogenesis. Furthermore, these polymorphic states may mask epidemiological relationships in clinical isolates. This project is designed to understand the mechanism of switching between morphological states and to provide DNA sequence markers that will identify particular strains of various Candida species and permit predictive diagnosis for drug sensitivity and other aspects of pathogenesis.

二态酵母，白色念珠菌都是人类病原体 和一个共生有机体，占据了许多位置 人体。 发现新的亚稳态形态状态 该生物的多态性导致了一个假设 大自然与发病机理有关。 此外，这些 多态状态可以掩盖流行病学关系 临床分离株。 该项目旨在了解 形态状态和TO之间切换的机制 提供将识别特定的DNA序列标记 各种念珠菌物种的菌株并允许预测性诊断 用于药物敏感性和发病机理的其他方面。