PLACENTAL TRANSFER & METABOLISM OF DRUGS FOR AIDS

胎盘移植

• 批准号: 3142625
• 负责人: JOSEPH DANCIS
• 金额: $ 10.31万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1992-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3142625
• 关键词: 2'3' dideoxynucleoside; AIDS therapy; adenosine; antiAIDS agent; deoxyadenosines; drug metabolism; female; glucose transport; high performance liquid chromatography; human tissue; nitrobenzene; perfusion; placental transfer; pregnancy circulation; thiopurine; thymidine; zidovudine

The infection of infants with AIDS generally occurs ante-or intra- partum. The logical approach to the prevention or reduction in the severity of infection is to treat the infected mother. The therapeutic agents that are currently under consideration for such use are nucleosides. It would be highly desirable to know the potential of exposure of the fetus to these agents while treating the mother. It is proposed to study in a perfusion system of human placenta the transfer and metabolism of AZT and dideoxyadenosine. Thymidine and adenosine, from which these and possible future drugs are derived, will also be studied. Efficient nucleoside transport systems have been described in cells from a variety of sources. Nothing is known about the human placenta.

用AIDS感染的感染通常发生在静脉内或 零件。 预防或减少的逻辑方法 感染的严重程度是治疗受感染的母亲。 这 目前正在考虑的治疗剂 使用是核苷。 非常希望知道 胎儿在​​治疗时暴露于这些药物的潜力 母亲。 有人建议在人类的灌注系统中研究 胎盘aZT和二氧化腺苷的转移和代谢。 胸苷和腺苷，从中这些药物和可能的未来药物 被得出，也将研究。 有效的核苷转运 在来自多种来源的细胞中已经描述了系统。 人类胎盘一无所知。

项目成果

Nucleoside transport by perfused human placenta.

通过灌注人胎盘进行核苷转运。

• DOI: 10.1016/s0143-4004(05)80207-3
• 发表时间: 1993
• 期刊: Placenta
• 影响因子: 3.8
• 作者: Dancis,J;Lee,J;Mendoza,S;Liebes,L
• 通讯作者: Liebes,L

Transfer of zidovudine (AZT) by human placenta.

通过人胎盘转移齐多夫定 (AZT)。

• DOI: 10.1093/infdis/161.2.203
• 发表时间: 1990
• 期刊: The Journal of infectious diseases
• 作者: Liebes,L;Mendoza,S;Wilson,D;Dancis,J
• 通讯作者: Dancis,J

Further observations on zidovudine transfer and metabolism by human placenta.

齐多夫定通过人胎盘转运和代谢的进一步观察。

• 发表时间: 1993
• 期刊: AIDS (London, England)
• 作者: Liebes,L;Mendoza,S;Lee,JD;Dancis,J
• 通讯作者: Dancis,J