INFANTS OF HTLV-III/LAV SEROPOSITIVE MOTHERS

HTLV-III/LAV 血清阳性母亲的婴儿

• 批准号: 3135766
• 负责人: GWENDOLYN SCOTT
• 金额: $ 45.89万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-03-01 至 1991-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3135766
• 关键词: AIDS; AIDS /HIV test; Caribbean; HIV infections; communicable disease transmission; disease /disorder proneness /risk; epidemiology; human immunodeficiency virus 1; human subject; infant human (0-1 year); longitudinal human study; molecular pathology; newborn human (0-6 weeks); sign /symptom

Among recent Haitian emigrants living in Miami the prevalence of serum antibodies to HTLV-III/LAV is 2-9%. Haitian-born women deliver between 2200 and 2500 infants annually at Jackson Memorial Hospital in Miami; approximately 20 of these infants will develop clinical evidence of HTLV-III/LAV infection each year. These deliveries constitute at least 90% of all births among Haitian emigrants in Dade County. We propose to determine the proportion of seropositive mothers that give birth to seropositive, virus-positive infants that develop clinical syndromes associated with HTLV-III/LAV infection. Seropositive and seronegative infants of seropositive mothers will be followed with a comparable number of seronegative infants of seronegative mothers for two years to assess their outcome. Information obtained from this population-based study will be of significance in two major areas. First, the information from the mothers will be used to assess the risks to unborn infants of women with HTLV-III/LAV infection. Second, the population-based character of the study will provide more complete information on the clinical spectrum of HTLV-III/LAV infection among infants in this population.

在最近居住在迈阿密的海地移民中，血清流行率 HTLV-III/LAV 抗体为 2-9%。 海地出生的妇女在 迈阿密杰克逊纪念医院每年收治 2200 名和 2500 名婴儿； 其中大约 20 名婴儿将出现以下临床证据： 每年 HTLV-III/LAV 感染。 这些交付量至少占 90% 戴德县海地移民的所有出生人口。 我们建议 确定生育的血清阳性母亲的比例 出现临床综合征的血清阳性、病毒阳性婴儿 与 HTLV-III/LAV 感染有关。 血清阳性和血清阴性 血清阳性母亲的婴儿将接受相当数量的跟踪 对血清阴性母亲所生的血清阴性婴儿进行两年的评估 他们的结果。 从这项基于人群的研究中获得的信息将 在两个主要领域具有重要意义。 首先，信息来自 母亲将被用来评估患有以下疾病的妇女对未出生婴儿的风险 HTLV-III/LAV 感染。 二、人口基数特征 研究将提供有关临床谱的更完整信息 该人群中婴儿的 HTLV-III/LAV 感染。