THIRST MECHANISMS IN AGING

衰老过程中的口渴机制

• 批准号: 3121982
• 负责人: NEIL Edward ROWLAND
• 金额: $ 12.32万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3121982
• 关键词: age difference; aging; aldosterone; angiotensins; appetite; atrial natriuretic peptide; autoradiography; biological models; body water dehydration; enzyme activity; excretion; gender difference; hormone receptor; laboratory rat; neuropeptide receptor; nutrition related tag; peptidyl dipeptidase A; renin; salt intake; thirst; water drinking behavior

The aim of this project is to provide an understanding of the mechanisms underlying the phenomenon of inadequate thirst in elderly people, and their resultant failure to fully correct states of dehydration. First, we will develop and characterize an animal model (rat) for aging deficits in thirst and sodium appetite, using two strains of rats and both males and females tested up to 20 months of age. These rats will be tested on a battery of tests of thirst and sodium appetite, using both natural and pharmacological stimulants, designed to engage and thus to probe selected know mechanisms of these behaviors. In parallel with the behavioral studies, the mechanism of the deficits will be examined, using measurements of various plasma hormones and brain peptide receptors. On the basis of preliminary findings, we will particularly focus attention on the responsiveness of components of the renin-angiotensin-aldosterone system as a function of age. Angiotensin will be administered both centrally and peripherally in thirst studies, and receptors for angiotensin will be measured in diencephalon and in the adrenal gland. Studies of salt intake will employ both angiotensin and mineralocorticoid-related stimuli of salt appetite. Spontaneous preference for NaCl will be determined. The effect of age on the temporal relationship of eating and drinking will be examined under both baseline conditions and during a switch of hydrationally-demanding diet. This will examine the flexibility of learned spontaneous drinking patterns in aging.

该项目的目的是提供对机制的理解 基本的是老年人不足的渴求现象， 他们结果无法完全纠正脱水状态。 第一的， 我们将开发并表征衰老缺陷的动物模型（大鼠） 在口渴和钠的食欲中，使用两种大鼠菌株和两种雄性 女性测试了20个月大。 这些大鼠将在 使用天然和自然的口渴和钠食欲测试 药理兴奋剂，旨在参与，从而探测选定的 了解这些行为的机制。 与行为平行 研究，将检查缺陷的机制，使用 各种血浆激素和脑肽受体的测量。 在 初步发现的基础，我们将特别集中注意力 关于肾素 - 血管紧张素 - 醛固酮成分的响应能力 系统作为年龄的函数。 血管紧张素将两者都施用 在口渴研究中的集中和周边，受体的受体 血管紧张素将在diencephalon和肾上腺中测量。 盐摄入研究将同时采用血管紧张素和 盐食欲的矿物皮质激素相关刺激。 自发的 将确定对NaCl的偏爱。 年龄对 饮食的时间关系将在两者下检查 基线条件以及在保湿饮食的转换期间。 这将研究自发饮酒的灵活性 衰老的模式。