NON-PHARMACOLOGIC TREATMENT OF SYSTOLIC HYPERTENSION

收缩期高血压的非药物治疗

• 批准号: 3790583
• 负责人: WILLIAM APPLEGATE
• 金额: --
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3790583
• 关键词: aging; antihypertensive agents; blood chemistry; blood pressure; cardiovascular stress test; clinical trials; data collection; diet therapy; dietary sodium; electrocardiography; health care cost /financing; human old age (65+); human subject; human therapy evaluation; hypertension; longitudinal human study; nutrition related tag; obesity; placebos; quality of life; questionnaires; therapy compliance; urinalysis; weight control

Isolated systolic hypertension (ISH) is a highly prevalent condition which is powerful risk factor for cardiovascular disease. The value of treating patients with ISH has yet to be proven, however, the results of the SHEP study will be available when this project is reviewed. The joint National Committee on Detection, Evaluation, and Treatment of high blood pressure recommends non-pharmacologic therapy for patients with ISH. Unfortunately the scientific basis for such advice is virtually non-existent. Thus there is a compelling rationale for initiating a clinical trial to evaluate the efficacy of non-pharmacologic therapy in ISH. This intervention development proposal is to conduct a feasibility study for a larger multi-center grant submission of a project to determine if non-pharmacologic interventions are effective in treating borderline or moderate isolate systolic hypertension. The ultimate multi-center grant for which this proposal is a feasibility study would possibly involve as many as 4 sites depending on sample size calculations. The feasibility study will assess in 120 persons age 30 - 80 years 1) the ability to develop lifestyle modification interventions which are appropriate for older persons, 2) the feasibility of recruitment, 3) to assess acceptability tolerance and adherence over 12 months, and 4) to pilot test the various measures proposed including quality of life. The overall goal of the proposed research is to identify and quantitate the role of the two most promising non-pharmacologic interventions in the treatment of persons 60 - 80 with a borderline isolated elevation of systolic blood pressure (140-160 mm Hg with diastolic pressure < 90 mm Hg). These interventions include prescription of low sodium diets to obese and non-obese individuals and a weight reducing diet in obese individuals. The significance of the proposed study is that the feasibility study would lead to a full trial to identify a safe well-tolerated and effective method of lowering systolic blood pressure in the elderly. The study findings will complement those to be provided by the SHEP study and may provide a means to reduce the current epidemic of blood pressure related cardiovascular disease in the elderly.

孤立的收缩高压（ISH）是一种高度普遍的疾病 是心血管疾病的强大危险因素。 治疗的价值 但是，ISH患者尚未得到证明，但是SHEP的结果 审查该项目时，将提供研究。 联合国民 高血压检测，评估和治疗委员会 建议针对ISH患者进行非药物治疗。 很遗憾 这种建议的科学基础实际上是不存在的。 因此 是启动临床试验来评估的令人信服的理由 非药物治疗在ISH中的功效。 这项干预发展建议是进行可行性研究 对于更大的多中心赠款提交项目的提交，以确定是否是否 非药物干预措施可有效治疗边界或 中等分离株收缩期高血压。 最终的多中心赠款 对于此提案，这是一项可行性研究可能涉及 根据样本量计算，多达4个站点。 可行性 研究将评估120人30-80年1） 制定适合的生活方式修改干预措施 老年人，2）招聘的可行性，3）评估 在12个月内的可接受性公差和依从性，4）进行试验测试 提出的各种措施，包括生活质量。 总体目标 拟议的研究是识别和量化两者的作用 最有希望的非药物干预措施 60-80具有收缩压的边界隔离升高 （舒张压<90 mm Hg）（140-160 mm Hg）。 这些干预措施 包括向肥胖和非肥胖个体的低钠饮食处方 以及减少肥胖个体饮食的体重。 意义的意义 拟议的研究是，可行性研究将导致全面试验 确定一种安全耐受良好且有效的降低收缩症的方法 老年人的血压。 研究结果将使这些结果补充 由SHEP研究提供，可能提供一种减少当前的方法 老年人的血压相关心血管疾病的流行。