NEUROTRAUMA CLINICAL RESEARCH CENTER

神经创伤临床研究中心

• 批准号: 3107864
• 负责人: MYRON DAVID GINSBERG
• 金额: $ 90.23万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1996-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3107864
• 关键词: brain injury; head /neck injury; hypothermia; trauma

We propose a Neurotrauma Clinical Research Center at the University of Miami/Jackson Memorial Hospital Medical Center. The Program consists of five projects in clinical and basic science, and a Clinical Epidemiology and Biostatistics Core, whose primary aims are to create a comprehensive patient registry; to develop and implement prognostic indicators of mortality/morbidity and outcome; and to provide ongoing support to present and future projects. The Projects are unified by their concern with potentially treatable or preventable pathomechanisms of traumatic CNS injury. The role of brain temperature in modulating post-traumatic CNS injury is a particular area of common concern. Program areas include: (a) the clinical evaluation of altered brain temperature in patients with severe acute head injury, analyzing the significance of brain hyperthermia in relation to altered intracranial pressure, CSF metabolites, and clinical outcome; (b) hippocampal dysfunction following fluid-percussion head injury in the rat, integrating electrophysiological, neurotransmitter, and behavioral measures; (c) an analysis of post-traumatic microvascular integrity, blood-brain barrier, and cortical circuit function in the head- injured rat in relation to altered brain temperature; (d) mechanisms of injury-induced acute astrocytic swelling, with a focus on calcium and calcium-dependent kinases; and (e) the therapeutic role of moderate hypothermia in experimental contusive spinal cord injury. Our program relies upon several unique and outstanding institutional resources a) a 1485-bed university-centered major medical center which receives the overwhelming majority of head-injury and spinal cord-injury cases in Dade County, with its 2 million population; b) a newly restructured Department of Epidemiology and Public Health with expertise in data registries and trial design; and c) major ongoing research programs in both cerebral metabolism/ischemic cerebrovascular disease and in spinal cord injury, providing breadth and depth of multidisciplinary collaborative expertise.

我们建议在大学 迈阿密/杰克逊纪念医院医疗中心。 该程序包括 临床和基础科学的五个项目以及临床流行病学 和生物统计学核心，其主要目的是创建一个全面的 患者注册表；制定和实施预后指标 死亡率/发病率和结果；并提供持续的支持以展示 和未来的项目。 这些项目因其关注而统一 可能治疗或可预防的创伤性中枢神经系统的病理机理 受伤。 大脑温度在调节创伤后中枢神经系统中的作用 伤害是一个普遍关注的特定领域。 计划领域包括：（a） 对患者大脑温度改变的临床评估 严重的急性头部损伤，分析大脑高温的重要性 关于颅内压的改变，CSF代谢物和临床 结果; （b）流体渗透头损伤后海马功能障碍 在大鼠中，整合电生理，神经递质和 行为措施； （c）创伤后微血管的分析 正直，血脑屏障和头部的皮质回路功能 与大脑温度改变有关的大鼠受伤； （d）机制 损伤引起的急性星形胶质细胞肿胀，重点是钙和 钙依赖性激酶； （e）中度的治疗作用 实验性抑制性脊髓损伤中的体温过低。 我们的计划 依靠几种独特而杰出的机构资源a）a） 1485年床以大学为中心的主要医疗中心接受 戴德（Dade）绝大多数头部受伤和脊髓伤害病例 县，拥有200万人口； b）新重组的部门 具有数据注册专业知识的流行病学和公共卫生和公共卫生 试用设计； c）两个大脑的主要正在进行的研究计划 代谢/缺血性脑血管疾病和脊髓损伤， 提供多学科协作专业知识的广度和深度。