SCOR-LUNG BIOLOGY AND DISEASES IN INFANTS AND CHILDREN

婴儿和儿童的 SCOR-肺生物学与疾病

• 批准号: 3106905
• 负责人: JOHN P. REEVES
• 金额: $ 94.57万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-12-30 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106905
• 关键词: human subject; newborn human (0-6 weeks); pulmonary hypertension

This proposal from the Department of Pediatrics, University of Colorado, seeks 5 year funding to establish a new program which investigates persistent pulmonary hypertension of the newborn (PPHN). PPHN is a relatively frequent (1:500 live births) disease of unknown origin associated with a high morbidity and mortality (25-50%) unless treated for days with invasive, expensive, and somewhat risky extracorporeal membrane oxygenation (ECMO). We propose to investigate initial insults (such as oxidant and hemodynamic stress) and mechanisms through which these insults lead to altered vasoreactivity and vascular remodeling (increased matrix, and vascular cell proliferation), clinical hallmarks of PPHN. Available for study are approximately 80-100 patients per year with established PPHN referred to The Children's Hospital, Denver, and 20 born to a high risk population at the University Hospital, where early detection procedures have been developed. Basic insights into mechanisms operating in PPHN will be from the patients, several animal models of neonatal pulmonary hypertension, and cellular and molecular studies. The data will allow early detection and interventions and better therapies aimed at effective vasodilation and restoration of depleted antioxidant defenses. The program will provide early detection, better treatment, and ultimately, prevention, of PPHN.

科罗拉多大学儿科系的这项提议， 寻求 5 年的资金来建立一个新的项目来调查 新生儿持续性肺动脉高压（PPHN）。 PPHN 是一个 相对常见（1:500 活产）的不明原因疾病 除非接受治疗，否则与高发病率和死亡率 (25-50%) 相关 连续几天进行侵入性、昂贵且有一定风险的体外治疗 膜氧合（ECMO）。 我们建议调查最初的损伤（例如氧化剂和 血流动力学压力）以及这些损伤导致的机制 改变血管反应性和血管重塑（增加基质和 血管细胞增殖），PPHN 的临床特征。 每年大约有 80-100 名患者可供研究 建立的 PPHN 称为丹佛儿童医院，以及 20 出生于大学医院的高危人群，早期 检测程序已经制定。机制的基本见解 PPHN 中的操作将来自患者、几种动物模型 新生儿肺动脉高压以及细胞和分子研究。这 数据将有助于早期发现和干预以及更好的治疗 旨在有效的血管舒张和恢复耗尽的抗氧化剂 防御。该计划将提供早期发现、更好的治疗、 最终，预防 PPHN。