SCOR-LUNG BIOLOGY AND DISEASES IN INFANTS AND CHILDREN

婴儿和儿童的 SCOR-肺生物学与疾病

• 批准号: 3106901
• 负责人: PHILIP M FARRELL
• 金额: $ 86.67万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-12-30 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106901
• 关键词: bronchopulmonary dysplasia; child (0-11); human subject; premature infant human; respiratory distress syndrome of newborn

The UW-Madison Specialized Center of Research on "Lung Biology and Disease in Infants and Children" will be devoted to elucidation of the pathobiology of bronchopulmonary dysplasia (BPD), particularly the delineation of cellular and biochemical mechanisms potentially important in either the pathogenesis of neonatal lung injury or the repair processes that facilitate recovery from chronic respiratory insufficiency of infants. This mission will be addressed in a multidisciplinary research program featuring a combination of interrelated basic and clinical investigations designed to expedite the development and application of new knowledge that might improve our understanding and treatment of bronchopulmonary dysplasia. There will be four research projects entitled: 1. Assessment of the role of oxyradicals in the pathogenesis of BPD. 2. Retinol function in the pathogenesis and repair of BPD. 3. Calcium-dependent phospholipid-binding proteins as related to lung development, RDS, and BPD. 4. Effect of hyperoxia on alveolar type II cell proliferation and differentiation during neonatal lung growth. These investigation, will be facilitated by three core units providing: a) administrative services; b) biostatistics/computing resources and assistance; and c) research coordinating support.

威斯康星大学麦迪逊分校“肺生物学与疾病”专业研究中心 婴儿和儿童”将致力于阐明病理学 支气管肺发育不良 (BPD)，特别是支气管肺发育不良 (BPD) 的描绘 细胞和生化机制在以下任一方面都可能很重要 新生儿肺损伤的发病机制或修复过程 促进婴儿慢性呼吸功能不全的恢复。 这一使命将通过多学科研究计划来实现 以相互关联的基础研究和临床研究相结合为特色 旨在加速新知识的开发和应用 可能会提高我们对支气管肺疾病的理解和治疗 发育不良。 将有四个研究项目，标题为： 1. 评估氧自由基在 BPD 发病机制中的作用。 2.视黄醇在BPD发病机制和修复中的作用。 3. 与肺相关的钙依赖性磷脂结合蛋白 开发、RDS 和 BPD。 4. 高氧对肺泡II型细胞增殖和增殖的影响 新生儿肺生长过程中的分化。 这些调查将由三个核心单位推动：a) 行政服务； b) 生物统计/计算资源和 协助; c) 研究协调支持。