NATIONAL STABLE ISOTOPES RESOURCE

国家稳定同位素资源

• 批准号: 3104076
• 负责人: JAMES A FEE
• 金额: $ 85万
• 依托单位: UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-12-01 至 1987-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3104076
• 关键词: alkylation; allied health education; aminoacid; biomedical resource; chemical synthesis; cryoscience; electron spin resonance spectroscopy; gas chromatography; glycine; information dissemination; mass spectrometry; nuclear magnetic resonance spectroscopy; radiopharmacology; silicon; stable isotope; stable isotope diagnosis; stereochemistry; sulfur compounds

Separated stable isotopes of carbon, nitrogen, and oxygen are presently produced by the Los Alamos Scientific Laboratory at the tens of kilograms per year level in a facility which is the world's largest and is the only one in the United States. The high production rate at sharply reduced costs has encouraged use of these isotopes in biomedical research and clinical studies. To expedite more general use of this new research tool, it is necessary to make labeled compounds more readily available to qualified investigators and, in many cases, to provide assistance in the analysis of experimental samples. We propose to continue the operation of a National, Stable isotopes Resource within the Los Alamos Scientific Laboratory, under the sponsorship of the National Institutes of Health (NIH), which will be responsive to the needs of the biomedical research community. The National Resource will continue to meet the needs cited above by: 1) Production of isotopes of carbon, nitrogen, and oxygen as required. 2) Synthesis of labeled compounds in response to requests by research workers according to priorities established by a national advisory committee. 3) Development of synthesis methods for compounds not now available. 4) Collaboration with qualified researchers in biomedical research which utilizes compounds with stable isotopes. 5) Operation of an educational program devoted to the effective production and use of stable isotope labeled compounds. 6) Support of core R&D at an appropriate level to improve and advance the above program.

目前已分离出碳、氮和氧的稳定同位素 洛斯阿拉莫斯科学实验室每年生产数十公斤 在世界上最大且是美国唯一的设施中 国家。 高生产率和大幅降低的成本鼓励了使用 这些同位素用于生物医学研究和临床研究。 为了加快更多 一般使用这种新的研究工具，有必要制作标记化合物 合格的调查人员更容易获得，并且在许多情况下，可以提供 协助分析实验样品。 我们建议继续 洛斯阿拉莫斯国家稳定同位素资源的运营 科学实验室，由美国国立研究院赞助 健康（NIH），将响应生物医学研究的需求 社区。 国家资源将继续满足上述需求 通过： 1) 根据需要生产碳、氮和氧的同位素。 2） 应研究人员的要求合成标记化合物 根据国家咨询委员会确定的优先事项。 3） 开发目前尚不可用的化合物的合成方法。 4） 与生物医学研究领域的合格研究人员合作，利用 具有稳定同位素的化合物。 5) 专门开展教育项目 稳定同位素标记化合物的有效生产和使用。 6） 在适当水平上支持核心研发，以改进和推进上述目标 程序。