Deciphering the immune complexity that orchestrates T cell activation

解读协调 T 细胞激活的免疫复杂性

• 批准号: DP240102062
• 负责人: Dr Daniel Utzschneider
• 金额: $ 36.51万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102062
• 关键词: Deciphering; immune; complexity; orchestrates; cell

The adaptive immune system consists of a complex cellular network that can efficiently distinguish exogenous required inputs, such as nutrients, from those that are potentially harmful like pathogens. Such ‘friend-foe’ discrimination has its molecular basis in a multitude of receptors with specificity to certain ligands. Critically, however, it is unclear how such discrimination is mechanistically regulated at the functional level. We have developed new and sophisticated experimental models that will allow us to systematically dissect and unfold the complexity of the adaptive immune system and address this critical knowledge gap. Expected outcomes will critically advance our general understanding of a fundamental biological principle.

自适应免疫学系统由一个复杂的细胞网络组成，该网络可以有效地区分外源所需的输入，例如养分，与那些像病原体一样有害的输入。这种“朋友 - 骗局”歧视在多种接收器中具有对某些配体特异性的分子基础。然而，至关重要的是，尚不清楚这种歧视是如何在功能水平上机械调节的。我们已经开发了新的，复杂的实验模型，使我们能够系统地剖析和展开适应性免疫系统的复杂性并解决这一关键知识差距。预期的结果将严格提高我们对基本生物学原理的一般理解。