PREVENTIVE ONCOLOGY ACADEMIC AWARD

预防肿瘤学学术奖

• 批准号: 3076774
• 负责人: DAVID H GARABRANT
• 金额: $ 7.54万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-12-10 至 1992-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3076774
• 关键词: body physical activity; cancer information system; cancer prevention; cancer registry /resource; cancer risk; carbopolycyclic compound; central nervous system neoplasms; chemical carcinogen; electromagnetic radiation; environment related neoplasm /cancer; glioma; human subject; hydrazines; industry; male; meningioma; nutrition related neoplasm /cancer; nutrition related tag; occupational hazard; petroleum oil; radiation carcinogen; solvents

This proposal describes the research projects that the applicant will conduct and the applicant's plans for professional development as a cancer prevention researcher during the proposed award period. The research will focus on etiologic studies of cancer in relation to exposure to chemicals, physical agents, and other occupational factors. The research will identify specific risk factors for which there is a strategy for prevention through the prevention of exposure or change in behavior. The applicant will broaden his background in analytic biostatistics and mechanisms of carcinogenesis, and will participate in the development of cancer prevention through the recognition and control of occupational exposures. Four studies are proposed: 1. A case-control study of 155 CNS tumor patients in the aircraft industry which will investigate the risks due to occupational exposures to specific chemicals, families of chemicals, and industrial processes. The factors under study include organic solvents, lubricants and machining fluids, polycyclic aromatic hydrocarbons, hydrazines, ionizing radiation, and work as machinist. 2. a case-control study of 350 CNS tumor patients among males 25-69 in the general population. The factors under study include specific chemicals, occupations, ionizing readiation and head trauma. This study will complement the first be addressing non- occupational factors as well as occupational factors. 3. A case-control study of 750 male and female colon cancer patients in relation to physical activity and diet. The emphasis is on the lifetime interaction between these two factors. This study developed from a more general approach to the use of variables derived from occupational data for hypothesis testing, which is described. 4. The use of tumor registry data for the systematic evaluation of cancer risk from occupational exposures. The applicant will develop an exposure classification system, systematically evaluate cancer risks for each exposure, and use empirical Bayes techniques to rank the associations to identify those that are more likely to be true.

该建议描述了申请人的研究项目 将进行和申请人的专业计划 作为预防癌症的研究人员的发展 拟议的奖励期。 该研究将重点放在病因上 癌症与暴露于化学物质有关的研究 代理商和其他职业因素。 该研究将确定 有预防策略的特定风险因素 通过预防暴露或行为变化。 这 申请人将扩大他在分析生物统计学方面的背景和 致癌机制，并将参与 通过识别和 控制职业暴露。 提出了四项研究： 1。对飞机中155例CNS肿瘤患者的病例对照研究 行业将调查因职业而引起的风险 暴露于特定的化学物质，化学药品家族和 工业过程。 研究的因素包括有机 溶剂，润滑剂和加工液，多环子芳香族 碳氢化合物，肼，电离辐射和工作 机械师。 2。男性350例CNS肿瘤患者的病例对照研究 一般人口为25-69。 研究的因素包括 特定的化学品，职业，电离读数和头部 创伤。 这项研究将补充第一个解决非 - 职业因素和职业因素。 3。对750个男性和女性结肠癌的病例对照研究 与体育锻炼和饮食有关的患者。 重点是 关于这两个因素之间的寿命相互作用。 这项研究 从更通用的方法发展到变量的使用 从用于假设检验的职业数据中得出 描述。 4。使用肿瘤注册表数据进行系统评估 职业暴露风险的风险。 申请人将 系统地开发曝光分类系统 评估每次暴露的癌症风险，并使用经验贝叶斯 排名关联的技术以识别那些 更可能是真实的。